Abstract
OBJECTIVES: To test a non-glycosylated recombinant human bone morphogenetic protein-2 (ngly-rhBMP-2)/fibrin composite, which has been shown experimentally to enhance healing of bone defects in rodents, in a clinical case series of dogs and cats undergoing treatment for fracture non-unions and arthrodesis. METHODS: A ngly-rhBMP-2/fibrin composite was applied in 41 sites in 38 dogs and cats for which a cancellous bone autograft was indicated, replacing the graft. RESULTS: Bridging of the bone defect with functional bone healing was achieved in 90 per cent of the arthrodesis and fracture non-unions treated in this manner. CLINICAL SIGNIFICANCE: This prospective clinical study demonstrates the beneficial effects of ngly-rhBMP-2 in a specially designed fibrin matrix on the treatment of bone defects, and validates the use of this composite as an alternative to bone autografts in dogs and cats.
| Original language | English |
|---|---|
| Pages (from-to) | 17-21 |
| Number of pages | 5 |
| Journal | Journal of Small Animal Practice |
| Volume | 46 |
| Issue number | 1 |
| State | Published - Jan 1 2005 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- veterinary(all)
Cite this
Enhancement of bone healing using non-glycosylated rhBMP-2 released from a fibrin matrix in dogs and cats. / Schmoekel, H. G.; Weber, F. E.; Hurter, K.; Schense, J. C.; Seiler, G.; Rytz, U.; Spreng, D.; Schawalder, P.; Hubbell, J.
In: Journal of Small Animal Practice, Vol. 46, No. 1, 01.01.2005, p. 17-21.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Enhancement of bone healing using non-glycosylated rhBMP-2 released from a fibrin matrix in dogs and cats
AU - Schmoekel, H. G.
AU - Weber, F. E.
AU - Hurter, K.
AU - Schense, J. C.
AU - Seiler, G.
AU - Rytz, U.
AU - Spreng, D.
AU - Schawalder, P.
AU - Hubbell, J.
PY - 2005/1/1
Y1 - 2005/1/1
N2 - OBJECTIVES: To test a non-glycosylated recombinant human bone morphogenetic protein-2 (ngly-rhBMP-2)/fibrin composite, which has been shown experimentally to enhance healing of bone defects in rodents, in a clinical case series of dogs and cats undergoing treatment for fracture non-unions and arthrodesis. METHODS: A ngly-rhBMP-2/fibrin composite was applied in 41 sites in 38 dogs and cats for which a cancellous bone autograft was indicated, replacing the graft. RESULTS: Bridging of the bone defect with functional bone healing was achieved in 90 per cent of the arthrodesis and fracture non-unions treated in this manner. CLINICAL SIGNIFICANCE: This prospective clinical study demonstrates the beneficial effects of ngly-rhBMP-2 in a specially designed fibrin matrix on the treatment of bone defects, and validates the use of this composite as an alternative to bone autografts in dogs and cats.
AB - OBJECTIVES: To test a non-glycosylated recombinant human bone morphogenetic protein-2 (ngly-rhBMP-2)/fibrin composite, which has been shown experimentally to enhance healing of bone defects in rodents, in a clinical case series of dogs and cats undergoing treatment for fracture non-unions and arthrodesis. METHODS: A ngly-rhBMP-2/fibrin composite was applied in 41 sites in 38 dogs and cats for which a cancellous bone autograft was indicated, replacing the graft. RESULTS: Bridging of the bone defect with functional bone healing was achieved in 90 per cent of the arthrodesis and fracture non-unions treated in this manner. CLINICAL SIGNIFICANCE: This prospective clinical study demonstrates the beneficial effects of ngly-rhBMP-2 in a specially designed fibrin matrix on the treatment of bone defects, and validates the use of this composite as an alternative to bone autografts in dogs and cats.
UR - http://www.scopus.com/inward/record.url?scp=12444323529&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=12444323529&partnerID=8YFLogxK
M3 - Article
C2 - 15682735
AN - SCOPUS:12444323529
VL - 46
SP - 17
EP - 21
JO - Journal of Small Animal Practice
JF - Journal of Small Animal Practice
SN - 0022-4510
IS - 1
ER -