Enhancement of bone healing using non-glycosylated rhBMP-2 released from a fibrin matrix in dogs and cats

H. G. Schmoekel; F. E. Weber; K. Hurter; J. C. Schense; G. Seiler; U. Rytz; D. Spreng; P. Schawalder; J. Hubbell

doi:10.1111/j.1748-5827.2005.tb00269.x

Enhancement of bone healing using non-glycosylated rhBMP-2 released from a fibrin matrix in dogs and cats

H. G. Schmoekel, F. E. Weber, K. Hurter, J. C. Schense, G. Seiler, U. Rytz, D. Spreng, P. Schawalder, J. Hubbell

Surgery

Research output: Contribution to journal › Article

17 Scopus citations

Abstract

OBJECTIVES: To test a non-glycosylated recombinant human bone morphogenetic protein-2 (ngly-rhBMP-2)/fibrin composite, which has been shown experimentally to enhance healing of bone defects in rodents, in a clinical case series of dogs and cats undergoing treatment for fracture non-unions and arthrodesis. METHODS: A ngly-rhBMP-2/fibrin composite was applied in 41 sites in 38 dogs and cats for which a cancellous bone autograft was indicated, replacing the graft. RESULTS: Bridging of the bone defect with functional bone healing was achieved in 90 per cent of the arthrodesis and fracture non-unions treated in this manner. CLINICAL SIGNIFICANCE: This prospective clinical study demonstrates the beneficial effects of ngly-rhBMP-2 in a specially designed fibrin matrix on the treatment of bone defects, and validates the use of this composite as an alternative to bone autografts in dogs and cats.

Original language	English (US)
Pages (from-to)	17-21
Number of pages	5
Journal	Journal of Small Animal Practice
Volume	46
Issue number	1
DOIs	https://doi.org/10.1111/j.1748-5827.2005.tb00269.x
State	Published - Jan 2005

ASJC Scopus subject areas

Small Animals

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Schmoekel, H. G., Weber, F. E., Hurter, K., Schense, J. C., Seiler, G., Rytz, U., Spreng, D., Schawalder, P., & Hubbell, J. (2005). Enhancement of bone healing using non-glycosylated rhBMP-2 released from a fibrin matrix in dogs and cats. Journal of Small Animal Practice, 46(1), 17-21. https://doi.org/10.1111/j.1748-5827.2005.tb00269.x

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abstract = "OBJECTIVES: To test a non-glycosylated recombinant human bone morphogenetic protein-2 (ngly-rhBMP-2)/fibrin composite, which has been shown experimentally to enhance healing of bone defects in rodents, in a clinical case series of dogs and cats undergoing treatment for fracture non-unions and arthrodesis. METHODS: A ngly-rhBMP-2/fibrin composite was applied in 41 sites in 38 dogs and cats for which a cancellous bone autograft was indicated, replacing the graft. RESULTS: Bridging of the bone defect with functional bone healing was achieved in 90 per cent of the arthrodesis and fracture non-unions treated in this manner. CLINICAL SIGNIFICANCE: This prospective clinical study demonstrates the beneficial effects of ngly-rhBMP-2 in a specially designed fibrin matrix on the treatment of bone defects, and validates the use of this composite as an alternative to bone autografts in dogs and cats.",

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AU - Weber, F. E.

AU - Hurter, K.

AU - Schense, J. C.

AU - Seiler, G.

AU - Rytz, U.

AU - Spreng, D.

AU - Schawalder, P.

AU - Hubbell, J.

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AB - OBJECTIVES: To test a non-glycosylated recombinant human bone morphogenetic protein-2 (ngly-rhBMP-2)/fibrin composite, which has been shown experimentally to enhance healing of bone defects in rodents, in a clinical case series of dogs and cats undergoing treatment for fracture non-unions and arthrodesis. METHODS: A ngly-rhBMP-2/fibrin composite was applied in 41 sites in 38 dogs and cats for which a cancellous bone autograft was indicated, replacing the graft. RESULTS: Bridging of the bone defect with functional bone healing was achieved in 90 per cent of the arthrodesis and fracture non-unions treated in this manner. CLINICAL SIGNIFICANCE: This prospective clinical study demonstrates the beneficial effects of ngly-rhBMP-2 in a specially designed fibrin matrix on the treatment of bone defects, and validates the use of this composite as an alternative to bone autografts in dogs and cats.

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