Enhancement of bone healing using non-glycosylated rhBMP-2 released from a fibrin matrix in dogs and cats

H. G. Schmoekel, F. E. Weber, K. Hurter, J. C. Schense, G. Seiler, U. Rytz, D. Spreng, P. Schawalder, J. Hubbell

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

OBJECTIVES: To test a non-glycosylated recombinant human bone morphogenetic protein-2 (ngly-rhBMP-2)/fibrin composite, which has been shown experimentally to enhance healing of bone defects in rodents, in a clinical case series of dogs and cats undergoing treatment for fracture non-unions and arthrodesis. METHODS: A ngly-rhBMP-2/fibrin composite was applied in 41 sites in 38 dogs and cats for which a cancellous bone autograft was indicated, replacing the graft. RESULTS: Bridging of the bone defect with functional bone healing was achieved in 90 per cent of the arthrodesis and fracture non-unions treated in this manner. CLINICAL SIGNIFICANCE: This prospective clinical study demonstrates the beneficial effects of ngly-rhBMP-2 in a specially designed fibrin matrix on the treatment of bone defects, and validates the use of this composite as an alternative to bone autografts in dogs and cats.

Original languageEnglish
Pages (from-to)17-21
Number of pages5
JournalJournal of Small Animal Practice
Volume46
Issue number1
StatePublished - Jan 1 2005
Externally publishedYes

Fingerprint

fibrin
Fibrin
Cats
bones
Dogs
cats
Bone and Bones
bone morphogenetic proteins
dogs
Arthrodesis
Autografts
Rodentia
Prospective Studies
clinical trials
Transplants
rodents
Therapeutics
recombinant human bone morphogenetic protein-2
testing

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Schmoekel, H. G., Weber, F. E., Hurter, K., Schense, J. C., Seiler, G., Rytz, U., ... Hubbell, J. (2005). Enhancement of bone healing using non-glycosylated rhBMP-2 released from a fibrin matrix in dogs and cats. Journal of Small Animal Practice, 46(1), 17-21.

Enhancement of bone healing using non-glycosylated rhBMP-2 released from a fibrin matrix in dogs and cats. / Schmoekel, H. G.; Weber, F. E.; Hurter, K.; Schense, J. C.; Seiler, G.; Rytz, U.; Spreng, D.; Schawalder, P.; Hubbell, J.

In: Journal of Small Animal Practice, Vol. 46, No. 1, 01.01.2005, p. 17-21.

Research output: Contribution to journalArticle

Schmoekel, HG, Weber, FE, Hurter, K, Schense, JC, Seiler, G, Rytz, U, Spreng, D, Schawalder, P & Hubbell, J 2005, 'Enhancement of bone healing using non-glycosylated rhBMP-2 released from a fibrin matrix in dogs and cats', Journal of Small Animal Practice, vol. 46, no. 1, pp. 17-21.
Schmoekel HG, Weber FE, Hurter K, Schense JC, Seiler G, Rytz U et al. Enhancement of bone healing using non-glycosylated rhBMP-2 released from a fibrin matrix in dogs and cats. Journal of Small Animal Practice. 2005 Jan 1;46(1):17-21.
Schmoekel, H. G. ; Weber, F. E. ; Hurter, K. ; Schense, J. C. ; Seiler, G. ; Rytz, U. ; Spreng, D. ; Schawalder, P. ; Hubbell, J. / Enhancement of bone healing using non-glycosylated rhBMP-2 released from a fibrin matrix in dogs and cats. In: Journal of Small Animal Practice. 2005 ; Vol. 46, No. 1. pp. 17-21.
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