Enhancement and demyelination of the intraorbital optic nerve: Fat suppression magnetic resonance imaging

John Guy, J. Mao, W. D. Bidgood, A. Mancuso, R. G. Quisling

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Conventional spin-echo magnetic resonance imaging (MRI) of intraorbital optic neuritis is hampered by the adjacent high signal and chemical shift artifact of orbital fat. Frequency-selective saturation pulse MRI reduces these problems and was used to determine its utility in evaluation of intraorbital optic neuritis. Eight consecutive patients with optic neuritis underwent MRI within 1 week of the onset of visual loss. Conventional MRI with T1, proton density, and T2 weighting and frequency-selective saturation pulse MRI with T1, proton density, and T2 weighting were performed. After administration of intravenous gadopentetate dimeglumine, T1-weighted conventional and frequency-selective saturation pulse MRI were performed. Frequency-selective saturation pulse MRI showed gadopentetate dimeglumine enhancement in the intraorbital optic nerve in 7 patients and the intracranial optic nerve in 3 patients. Conventional MRI failed to show optic nerve gadopentetate dimeglumine enhancement in patients with intraorbital lesions, but did show intracranial lesions. Frequency-selective saturation pulse MRI showed bilateral optic nerve enhancement in 3 patients with unilateral visual signs and symptoms. Proton density and T2-weighted conventional MRI of the brain showed no convincing signal aberrations in the optic nerves. In the MRI evaluation of intraorbital optic neuritis: (1) frequency-selective saturation pulse fat suppression MRI is superior to T1- weighted conventional MRI in the detection of gadopentetate dimeglumine enhancement; (2) frequency-selective saturation pulse proton density and T2- weighted MRI is superior to proton density and T2-weighted conventional MRI; (3) frequency-selective saturation pulse MRI showed gadopentetate dimeglumine enhancement as well as proton density/T2-weighted signal aberration in exactly the same portion of the intraorbital optic nerve.

Original languageEnglish
Pages (from-to)713-719
Number of pages7
JournalOphthalmology
Volume99
Issue number5
StatePublished - Jun 10 1992
Externally publishedYes

Fingerprint

Demyelinating Diseases
Optic Nerve
Fats
Magnetic Resonance Imaging
Gadolinium DTPA
Protons
Optic Neuritis
Intravenous Administration
Artifacts
Signs and Symptoms

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Guy, J., Mao, J., Bidgood, W. D., Mancuso, A., & Quisling, R. G. (1992). Enhancement and demyelination of the intraorbital optic nerve: Fat suppression magnetic resonance imaging. Ophthalmology, 99(5), 713-719.

Enhancement and demyelination of the intraorbital optic nerve : Fat suppression magnetic resonance imaging. / Guy, John; Mao, J.; Bidgood, W. D.; Mancuso, A.; Quisling, R. G.

In: Ophthalmology, Vol. 99, No. 5, 10.06.1992, p. 713-719.

Research output: Contribution to journalArticle

Guy, J, Mao, J, Bidgood, WD, Mancuso, A & Quisling, RG 1992, 'Enhancement and demyelination of the intraorbital optic nerve: Fat suppression magnetic resonance imaging', Ophthalmology, vol. 99, no. 5, pp. 713-719.
Guy, John ; Mao, J. ; Bidgood, W. D. ; Mancuso, A. ; Quisling, R. G. / Enhancement and demyelination of the intraorbital optic nerve : Fat suppression magnetic resonance imaging. In: Ophthalmology. 1992 ; Vol. 99, No. 5. pp. 713-719.
@article{18102d1fe90e4dc0b8f46a6b593bfc50,
title = "Enhancement and demyelination of the intraorbital optic nerve: Fat suppression magnetic resonance imaging",
abstract = "Conventional spin-echo magnetic resonance imaging (MRI) of intraorbital optic neuritis is hampered by the adjacent high signal and chemical shift artifact of orbital fat. Frequency-selective saturation pulse MRI reduces these problems and was used to determine its utility in evaluation of intraorbital optic neuritis. Eight consecutive patients with optic neuritis underwent MRI within 1 week of the onset of visual loss. Conventional MRI with T1, proton density, and T2 weighting and frequency-selective saturation pulse MRI with T1, proton density, and T2 weighting were performed. After administration of intravenous gadopentetate dimeglumine, T1-weighted conventional and frequency-selective saturation pulse MRI were performed. Frequency-selective saturation pulse MRI showed gadopentetate dimeglumine enhancement in the intraorbital optic nerve in 7 patients and the intracranial optic nerve in 3 patients. Conventional MRI failed to show optic nerve gadopentetate dimeglumine enhancement in patients with intraorbital lesions, but did show intracranial lesions. Frequency-selective saturation pulse MRI showed bilateral optic nerve enhancement in 3 patients with unilateral visual signs and symptoms. Proton density and T2-weighted conventional MRI of the brain showed no convincing signal aberrations in the optic nerves. In the MRI evaluation of intraorbital optic neuritis: (1) frequency-selective saturation pulse fat suppression MRI is superior to T1- weighted conventional MRI in the detection of gadopentetate dimeglumine enhancement; (2) frequency-selective saturation pulse proton density and T2- weighted MRI is superior to proton density and T2-weighted conventional MRI; (3) frequency-selective saturation pulse MRI showed gadopentetate dimeglumine enhancement as well as proton density/T2-weighted signal aberration in exactly the same portion of the intraorbital optic nerve.",
author = "John Guy and J. Mao and Bidgood, {W. D.} and A. Mancuso and Quisling, {R. G.}",
year = "1992",
month = "6",
day = "10",
language = "English",
volume = "99",
pages = "713--719",
journal = "Ophthalmology",
issn = "0161-6420",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Enhancement and demyelination of the intraorbital optic nerve

T2 - Fat suppression magnetic resonance imaging

AU - Guy, John

AU - Mao, J.

AU - Bidgood, W. D.

AU - Mancuso, A.

AU - Quisling, R. G.

PY - 1992/6/10

Y1 - 1992/6/10

N2 - Conventional spin-echo magnetic resonance imaging (MRI) of intraorbital optic neuritis is hampered by the adjacent high signal and chemical shift artifact of orbital fat. Frequency-selective saturation pulse MRI reduces these problems and was used to determine its utility in evaluation of intraorbital optic neuritis. Eight consecutive patients with optic neuritis underwent MRI within 1 week of the onset of visual loss. Conventional MRI with T1, proton density, and T2 weighting and frequency-selective saturation pulse MRI with T1, proton density, and T2 weighting were performed. After administration of intravenous gadopentetate dimeglumine, T1-weighted conventional and frequency-selective saturation pulse MRI were performed. Frequency-selective saturation pulse MRI showed gadopentetate dimeglumine enhancement in the intraorbital optic nerve in 7 patients and the intracranial optic nerve in 3 patients. Conventional MRI failed to show optic nerve gadopentetate dimeglumine enhancement in patients with intraorbital lesions, but did show intracranial lesions. Frequency-selective saturation pulse MRI showed bilateral optic nerve enhancement in 3 patients with unilateral visual signs and symptoms. Proton density and T2-weighted conventional MRI of the brain showed no convincing signal aberrations in the optic nerves. In the MRI evaluation of intraorbital optic neuritis: (1) frequency-selective saturation pulse fat suppression MRI is superior to T1- weighted conventional MRI in the detection of gadopentetate dimeglumine enhancement; (2) frequency-selective saturation pulse proton density and T2- weighted MRI is superior to proton density and T2-weighted conventional MRI; (3) frequency-selective saturation pulse MRI showed gadopentetate dimeglumine enhancement as well as proton density/T2-weighted signal aberration in exactly the same portion of the intraorbital optic nerve.

AB - Conventional spin-echo magnetic resonance imaging (MRI) of intraorbital optic neuritis is hampered by the adjacent high signal and chemical shift artifact of orbital fat. Frequency-selective saturation pulse MRI reduces these problems and was used to determine its utility in evaluation of intraorbital optic neuritis. Eight consecutive patients with optic neuritis underwent MRI within 1 week of the onset of visual loss. Conventional MRI with T1, proton density, and T2 weighting and frequency-selective saturation pulse MRI with T1, proton density, and T2 weighting were performed. After administration of intravenous gadopentetate dimeglumine, T1-weighted conventional and frequency-selective saturation pulse MRI were performed. Frequency-selective saturation pulse MRI showed gadopentetate dimeglumine enhancement in the intraorbital optic nerve in 7 patients and the intracranial optic nerve in 3 patients. Conventional MRI failed to show optic nerve gadopentetate dimeglumine enhancement in patients with intraorbital lesions, but did show intracranial lesions. Frequency-selective saturation pulse MRI showed bilateral optic nerve enhancement in 3 patients with unilateral visual signs and symptoms. Proton density and T2-weighted conventional MRI of the brain showed no convincing signal aberrations in the optic nerves. In the MRI evaluation of intraorbital optic neuritis: (1) frequency-selective saturation pulse fat suppression MRI is superior to T1- weighted conventional MRI in the detection of gadopentetate dimeglumine enhancement; (2) frequency-selective saturation pulse proton density and T2- weighted MRI is superior to proton density and T2-weighted conventional MRI; (3) frequency-selective saturation pulse MRI showed gadopentetate dimeglumine enhancement as well as proton density/T2-weighted signal aberration in exactly the same portion of the intraorbital optic nerve.

UR - http://www.scopus.com/inward/record.url?scp=0026751619&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026751619&partnerID=8YFLogxK

M3 - Article

C2 - 1594216

AN - SCOPUS:0026751619

VL - 99

SP - 713

EP - 719

JO - Ophthalmology

JF - Ophthalmology

SN - 0161-6420

IS - 5

ER -