Enhanced tyrosine phosphorylation in B lymphocytes upon complexing of membrane immunoglobulin

Andre E. Nel, Gary E. Landreth, Pascal J. Goldschmidt-Clermont, H. Edward Tung, Robert M. Galbraith

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Activation of normal human perioheral blood B-enriched lymphocytes with antiserum reacting with membrane immunoglobulin was associated with increased phosphorylation of ceilular proteins, particularly in the Triton-insoluble cytoskelutal fraction. At least two proteins (56K and 60K) were labeled predominantly at tyrosine residues. These findings may indicate another specialized membrane structure which upon specific ligand binding stimulates tyrosine phosphorylation in association with cellular proliferation.

Original languageEnglish (US)
Pages (from-to)859-866
Number of pages8
JournalBiochemical and biophysical research communications
Volume125
Issue number3
DOIs
StatePublished - Dec 28 1984

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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