Enhanced tyrosine phosphorylation in B lymphocytes upon complexing of membrane immunoglobulin

Andre E. Nel; Gary E. Landreth; Pascal J. Goldschmidt-Clermont; H. Edward Tung; Robert M. Galbraith

doi:10.1016/0006-291X(84)91362-7

Enhanced tyrosine phosphorylation in B lymphocytes upon complexing of membrane immunoglobulin

Andre E. Nel, Gary E. Landreth, Pascal J. Goldschmidt-Clermont, H. Edward Tung, Robert M. Galbraith

Medicine

Research output: Contribution to journal › Article

14 Scopus citations

Abstract

Activation of normal human perioheral blood B-enriched lymphocytes with antiserum reacting with membrane immunoglobulin was associated with increased phosphorylation of ceilular proteins, particularly in the Triton-insoluble cytoskelutal fraction. At least two proteins (56K and 60K) were labeled predominantly at tyrosine residues. These findings may indicate another specialized membrane structure which upon specific ligand binding stimulates tyrosine phosphorylation in association with cellular proliferation.

Original language	English (US)
Pages (from-to)	859-866
Number of pages	8
Journal	Biochemical and biophysical research communications
Volume	125
Issue number	3
DOIs	https://doi.org/10.1016/0006-291X(84)91362-7
State	Published - Dec 28 1984

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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Nel, A. E., Landreth, G. E., Goldschmidt-Clermont, P. J., Tung, H. E., & Galbraith, R. M. (1984). Enhanced tyrosine phosphorylation in B lymphocytes upon complexing of membrane immunoglobulin. Biochemical and biophysical research communications, 125(3), 859-866. https://doi.org/10.1016/0006-291X(84)91362-7

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AU - Galbraith, Robert M.

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