Activation of normal human perioheral blood B-enriched lymphocytes with antiserum reacting with membrane immunoglobulin was associated with increased phosphorylation of ceilular proteins, particularly in the Triton-insoluble cytoskelutal fraction. At least two proteins (56K and 60K) were labeled predominantly at tyrosine residues. These findings may indicate another specialized membrane structure which upon specific ligand binding stimulates tyrosine phosphorylation in association with cellular proliferation.
|Original language||English (US)|
|Number of pages||8|
|Journal||Biochemical and biophysical research communications|
|State||Published - Dec 28 1984|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology