Enhanced tumor formation in mice heterozygous for Blm mutation

Kathleen Heppner Goss, Mary A. Risinger, Jennifer J. Kordich, Maureen H. Sanz, Joel E. Straughen, Lisa E. Slovek, Anthony J Capobianco, James German, Gregory P. Boivin, Joanna Groden

Research output: Contribution to journalArticle

153 Citations (Scopus)

Abstract

Persons with the autosomal recessive disorder Bloom syndrome are predisposed to cancers of many types due to loss-of-function mutations in the BLM gene, which encodes a recQ-like helicase. Here we show that mice heterozygous for a targeted null mutation of Blm, the murine homolog of BLM, develop lymphoma earlier than wild-type littermates in response to challenge with murine leukemia virus and develop twice the number of intestinal tumors when crossed with mice carrying a mutation in the Apc tumor suppressor. These observations indicate that Blm is a modifier of tumor formation in the mouse and that Blm haploinsufficiency is associated with tumor predisposition, a finding with important implications for cancer risk in humans.

Original languageEnglish
Pages (from-to)2051-2053
Number of pages3
JournalScience
Volume297
Issue number5589
DOIs
StatePublished - Sep 20 2002
Externally publishedYes

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Mutation
Neoplasms
RecQ Helicases
Bloom Syndrome
Haploinsufficiency
Murine Leukemia Viruses
Lymphoma
Genes

ASJC Scopus subject areas

  • General

Cite this

Goss, K. H., Risinger, M. A., Kordich, J. J., Sanz, M. H., Straughen, J. E., Slovek, L. E., ... Groden, J. (2002). Enhanced tumor formation in mice heterozygous for Blm mutation. Science, 297(5589), 2051-2053. https://doi.org/10.1126/science.1074340

Enhanced tumor formation in mice heterozygous for Blm mutation. / Goss, Kathleen Heppner; Risinger, Mary A.; Kordich, Jennifer J.; Sanz, Maureen H.; Straughen, Joel E.; Slovek, Lisa E.; Capobianco, Anthony J; German, James; Boivin, Gregory P.; Groden, Joanna.

In: Science, Vol. 297, No. 5589, 20.09.2002, p. 2051-2053.

Research output: Contribution to journalArticle

Goss, KH, Risinger, MA, Kordich, JJ, Sanz, MH, Straughen, JE, Slovek, LE, Capobianco, AJ, German, J, Boivin, GP & Groden, J 2002, 'Enhanced tumor formation in mice heterozygous for Blm mutation', Science, vol. 297, no. 5589, pp. 2051-2053. https://doi.org/10.1126/science.1074340
Goss KH, Risinger MA, Kordich JJ, Sanz MH, Straughen JE, Slovek LE et al. Enhanced tumor formation in mice heterozygous for Blm mutation. Science. 2002 Sep 20;297(5589):2051-2053. https://doi.org/10.1126/science.1074340
Goss, Kathleen Heppner ; Risinger, Mary A. ; Kordich, Jennifer J. ; Sanz, Maureen H. ; Straughen, Joel E. ; Slovek, Lisa E. ; Capobianco, Anthony J ; German, James ; Boivin, Gregory P. ; Groden, Joanna. / Enhanced tumor formation in mice heterozygous for Blm mutation. In: Science. 2002 ; Vol. 297, No. 5589. pp. 2051-2053.
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