Experimental allergic encephalomelitis (EAE) in rats was used to study the immunosuppressive properties of 6-mercaptopurine (6-MP) and a glutamine antagonist, Duazomycin A (DZM), alone and in combination. The results indicate that while DZM alone had no immunosuppressive activity, it significantly enhanced the effectiveness of 6-MP in this disorder without increasing toxicity. The favorable results with this rational combination of antimetabolities in an experimental â€œauto-immuneâ€� disease associated with delayed hypersensitivity suggests similar applicability to disorders characterized by altered immune reactivity in man.
|Original language||English (US)|
|Number of pages||6|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - May 1969|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)