Enhanced Suppression of Experimental Allergic Encephalomyelitis by Combination Chemotherapy with Duazomycin-A and 6-Mercaptopurine

Charles L. Vogel, Paul Calabresi

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Experimental allergic encephalomelitis (EAE) in rats was used to study the immunosuppressive properties of 6-mercaptopurine (6-MP) and a glutamine antagonist, Duazomycin A (DZM), alone and in combination. The results indicate that while DZM alone had no immunosuppressive activity, it significantly enhanced the effectiveness of 6-MP in this disorder without increasing toxicity. The favorable results with this rational combination of antimetabolities in an experimental “auto-immune� disease associated with delayed hypersensitivity suggests similar applicability to disorders characterized by altered immune reactivity in man.

Original languageEnglish (US)
Pages (from-to)251-256
Number of pages6
JournalProceedings of the Society for Experimental Biology and Medicine
Volume131
Issue number1
DOIs
StatePublished - May 1969
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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