Enhanced Soluble Serum CD40L and Serum P-Selectin Levels in Primary Aldosteronism

L. Petramala, Gianluca Iacobellis, R. Carnevale, C. Marinelli, L. Zinnamosca, A. Concistrè, M. Galassi, G. Iannucci, P. Lucia, P. Pignatelli, A. Ciardi, F. Violi, G. De Toma, C. Letizia

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Primary aldosteronism (PA) is one of the most frequent forms of secondary hypertension, associated with atherosclerosis and higher risk of cardiovascular events. Platelets play a key role in the atherosclerotic process. The aim of the study was to evaluate the platelet activation by measuring serum levels of soluble CD40L (sCD40L) and P-selectin (sP-selectin) in consecutive PA patients [subgroup: aldosterone-secreting adrenal adenoma (APA) and bilateral adrenal hyperplasia (IHA)], matched with essential hypertensive (EH) patients. The subgroup of APA patients was revaluated 6-months after unilateral adrenalectomy. In all PA group, we measured higher serum levels of both sP-selectin (14.29±9.33 pg/ml) and sCD40L (9.53±4.2 ng/ml) compared to EH patients (9.39±5.3 pg/ml and 3.54±0.94 ng/ml, respectively; p<0.001). After removal of APA, PA patients showed significant reduction of blood pressure (BP) values, plasma aldosterone (PAC) levels and ARR-ratio, associated with a significant reduction of sP-selectin (16.74±8.9 pg/ml vs. 8.1±3.8 pg/ml; p<0.01) and sCD40L (8.6±1 ng/ml vs. 5.24±0.94 ng/ml; p<0.001). In PA patients, we found a significant correlation between sP-selectin and sCD40L with PAC (r=0.52, p<0.01; r=0.50, p<0.01, respectively); this correlation was stronger in APA patients (r=0.54; p<0.01 r=0.63; p<0.01, respectively). Our results showed that PA is related to platelet activation, expressed as higher plasma values of sCD40L and sP-selectin values. Surgical treatment and consequent normalization of aldosterone secretion was associated with significant reduction of sCD40L and sP-selectin values in APA patients.

Original languageEnglish (US)
Pages (from-to)440-445
Number of pages6
JournalHormone and Metabolic Research
Volume48
Issue number7
DOIs
StatePublished - Jul 1 2016

Fingerprint

CD40 Ligand
Hyperaldosteronism
P-Selectin
Platelets
Aldosterone
Serum
Platelet Activation
Chemical activation
Plasmas
Blood pressure
Adrenalectomy
Adenoma
Hyperplasia
Atherosclerosis
Blood Platelets
Blood Pressure
Hypertension

Keywords

  • CD40
  • p-selectin
  • platelet activation
  • primary aldosteronism

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Petramala, L., Iacobellis, G., Carnevale, R., Marinelli, C., Zinnamosca, L., Concistrè, A., ... Letizia, C. (2016). Enhanced Soluble Serum CD40L and Serum P-Selectin Levels in Primary Aldosteronism. Hormone and Metabolic Research, 48(7), 440-445. https://doi.org/10.1055/s-0042-103588

Enhanced Soluble Serum CD40L and Serum P-Selectin Levels in Primary Aldosteronism. / Petramala, L.; Iacobellis, Gianluca; Carnevale, R.; Marinelli, C.; Zinnamosca, L.; Concistrè, A.; Galassi, M.; Iannucci, G.; Lucia, P.; Pignatelli, P.; Ciardi, A.; Violi, F.; De Toma, G.; Letizia, C.

In: Hormone and Metabolic Research, Vol. 48, No. 7, 01.07.2016, p. 440-445.

Research output: Contribution to journalArticle

Petramala, L, Iacobellis, G, Carnevale, R, Marinelli, C, Zinnamosca, L, Concistrè, A, Galassi, M, Iannucci, G, Lucia, P, Pignatelli, P, Ciardi, A, Violi, F, De Toma, G & Letizia, C 2016, 'Enhanced Soluble Serum CD40L and Serum P-Selectin Levels in Primary Aldosteronism', Hormone and Metabolic Research, vol. 48, no. 7, pp. 440-445. https://doi.org/10.1055/s-0042-103588
Petramala, L. ; Iacobellis, Gianluca ; Carnevale, R. ; Marinelli, C. ; Zinnamosca, L. ; Concistrè, A. ; Galassi, M. ; Iannucci, G. ; Lucia, P. ; Pignatelli, P. ; Ciardi, A. ; Violi, F. ; De Toma, G. ; Letizia, C. / Enhanced Soluble Serum CD40L and Serum P-Selectin Levels in Primary Aldosteronism. In: Hormone and Metabolic Research. 2016 ; Vol. 48, No. 7. pp. 440-445.
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