Enhanced siderophore production and mouse kidney pathogenicity in Escherichia coli grown in urine

S. Sharma, K. Harjai, R. Mittal

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Fifteen siderophore producing urinary isolates of Escherichia coli were compared for aerobactin and enterochelin production in trypticase soy broth and pooled normal human urine. Significant increase in siderophore production (both phenolate and hydroxamate) was observed when organisms were grown in urine. Mouse kidney pathogenic potential of the strains grown in urine was compared with that of bacteria grown in trypticase soy broth in an ascending model of pyelonephritis in female Swiss Webster mice. Organisms grown in urine and instilled into a mouse bladder demonstrated markedly enhanced renal pathogenicity (p < 0.01). Further information about the influence of urinary constituents on siderophore production could help in understanding the pathogenesis of pyelonephritis.

Original languageEnglish (US)
Pages (from-to)325-329
Number of pages5
JournalJournal of Medical Microbiology
Volume35
Issue number6
DOIs
StatePublished - 1991
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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