Enhanced in vitro bone marrow cell migration and T-lymphocyte responses in aged mice given subcutaneous thymic epithelial cell grafts

Jack L. Haar, Jeffery K. Taubenberger, Leigh Doane, Norma Kenyon

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Thymic epithelial cell cultures from newborn CBA/J mice were developed and grown on collagen-coated dextran beads. These thymic epithelial cells were transplanted subcutaneously into aged syngeneic mice. After several weeks, enhanced in vitro migration of host bone marrow cells occurred to supernatants prepared from neonatal thymus cultures in thymic epithelial cell grafted mice compared to control aged mice. Percent migration equaled that of migration from control young adult mice. In addition, enhanced T-lymphocyte responses were observed in aged mice given thymic epithelial cell grafts as compared to aged controls.

Original languageEnglish (US)
Pages (from-to)207-219
Number of pages13
JournalMechanisms of Ageing and Development
Volume47
Issue number3
DOIs
StatePublished - Mar 1989
Externally publishedYes

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Keywords

  • Aging
  • Bone marrow
  • Immunosenescence
  • T-lymphocytes
  • Thymic epithelial cells

ASJC Scopus subject areas

  • Aging
  • Biochemistry
  • Developmental Biology
  • Developmental Neuroscience

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