Engineering tissues, organs and cells

Anthony Atala

Research output: Contribution to journalReview articlepeer-review

141 Scopus citations

Abstract

Patients suffering from diseased and injured organs may be treated with transplanted organs; however, there is a severe shortage of donor organs that is worsening yearly, given the ageing population. In the field of regenerative medicine and tissue engineering, scientists apply the principles of cell transplantation, materials science and bioengineering to construct biological substitutes that will restore and maintain normal function in diseased and injured tissues. Therapeutic cloning, where the nucleus from a donor cell is transferred into an enucleated oocyte in order to extract pluripotent embryonic stem cells, offers a potentially limitless source of cells for tissue engineering applications. The stem cell field is also advancing rapidly, opening new options for therapy, including the use of amniotic and placental fetal stem cells. This review covers recent advances that have occurred in regenerative medicine and describes applications of these technologies using chemical compounds that may offer novel therapies for patients with end-stage organ failure.

Original languageEnglish (US)
Pages (from-to)83-96
Number of pages14
JournalJournal of Tissue Engineering and Regenerative Medicine
Volume1
Issue number2
DOIs
StatePublished - Mar 2007

Keywords

  • Biomaterials
  • Bladder
  • Genital tissues
  • Kidney
  • Regenerative medicine
  • Stem cells
  • Tissue engineering
  • Urethra

ASJC Scopus subject areas

  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Medicine(all)

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