Engineering functional bladder tissues

Maya Horst, Srinivas Madduri, Rita Gobet, Tullio Sulser, Vinzent Milleret, Heike Hall, Anthony Atala, Daniel Eberli

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Purpose: End stage bladder disease can seriously affect patient quality of life and often requires surgical reconstruction with bowel tissue, which is associated with numerous complications. Bioengineering of functional bladder tissue using tissue-engineering techniques could provide new functional tissues for reconstruction. In this review, we discuss the current state of this field and address different approaches to enable physiologic voiding in engineered bladder tissues in the near future. Materials and Methods: In a collaborative effort, we gathered researchers from four institutions to discuss the current state of functional bladder engineering. A MEDLINE® and PubMed® search was conducted for articles related to tissue engineering of the bladder, with special focus on the cells and biomaterials employed as well as the microenvironment, vascularisation and innervation strategies used. Results: Over the last decade, advances in tissue engineering technology have laid the groundwork for the development of a biological substitute for bladder tissue that can support storage of urine and restore physiologic voiding. Although many researchers have been able to demonstrate the formation of engineered tissue with a structure similar to that of native bladder tissue, restoration of physiologic voiding using these constructs has never been demonstrated. The main issues hindering the development of larger contractile tissues that allow physiologic voiding include the development of correct muscle alignment, proper innervation and vascularization. Conclusion: Tissue engineering of a construct that will support the contractile properties that allow physiologic voiding is a complex process. The combination of smart scaffolds with controlled topography, the ability to deliver multiple trophic factors and an optimal cell source will allow for the engineering of functional bladder tissues in the near future.

Original languageEnglish
Pages (from-to)515-522
Number of pages8
JournalJournal of Tissue Engineering and Regenerative Medicine
Volume7
Issue number7
DOIs
StatePublished - Jul 1 2013
Externally publishedYes

Fingerprint

Urinary Bladder
Tissue
Tissue Engineering
Tissue engineering
Urinary Bladder Diseases
Research Personnel
Bioengineering
Muscle Development
Engineering technology
Biocompatible Materials
PubMed
Biomaterials
Scaffolds
MEDLINE
Topography
Restoration
Muscle
Quality of Life
Urine
Technology

Keywords

  • Bioengineering
  • Functional bladder tissue
  • Innervation
  • Scaffolds
  • Vascularization

ASJC Scopus subject areas

  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Biomaterials

Cite this

Horst, M., Madduri, S., Gobet, R., Sulser, T., Milleret, V., Hall, H., ... Eberli, D. (2013). Engineering functional bladder tissues. Journal of Tissue Engineering and Regenerative Medicine, 7(7), 515-522. https://doi.org/10.1002/term.547

Engineering functional bladder tissues. / Horst, Maya; Madduri, Srinivas; Gobet, Rita; Sulser, Tullio; Milleret, Vinzent; Hall, Heike; Atala, Anthony; Eberli, Daniel.

In: Journal of Tissue Engineering and Regenerative Medicine, Vol. 7, No. 7, 01.07.2013, p. 515-522.

Research output: Contribution to journalArticle

Horst, M, Madduri, S, Gobet, R, Sulser, T, Milleret, V, Hall, H, Atala, A & Eberli, D 2013, 'Engineering functional bladder tissues', Journal of Tissue Engineering and Regenerative Medicine, vol. 7, no. 7, pp. 515-522. https://doi.org/10.1002/term.547
Horst M, Madduri S, Gobet R, Sulser T, Milleret V, Hall H et al. Engineering functional bladder tissues. Journal of Tissue Engineering and Regenerative Medicine. 2013 Jul 1;7(7):515-522. https://doi.org/10.1002/term.547
Horst, Maya ; Madduri, Srinivas ; Gobet, Rita ; Sulser, Tullio ; Milleret, Vinzent ; Hall, Heike ; Atala, Anthony ; Eberli, Daniel. / Engineering functional bladder tissues. In: Journal of Tissue Engineering and Regenerative Medicine. 2013 ; Vol. 7, No. 7. pp. 515-522.
@article{78a693b7937545949b7531d9248d1faf,
title = "Engineering functional bladder tissues",
abstract = "Purpose: End stage bladder disease can seriously affect patient quality of life and often requires surgical reconstruction with bowel tissue, which is associated with numerous complications. Bioengineering of functional bladder tissue using tissue-engineering techniques could provide new functional tissues for reconstruction. In this review, we discuss the current state of this field and address different approaches to enable physiologic voiding in engineered bladder tissues in the near future. Materials and Methods: In a collaborative effort, we gathered researchers from four institutions to discuss the current state of functional bladder engineering. A MEDLINE{\circledR} and PubMed{\circledR} search was conducted for articles related to tissue engineering of the bladder, with special focus on the cells and biomaterials employed as well as the microenvironment, vascularisation and innervation strategies used. Results: Over the last decade, advances in tissue engineering technology have laid the groundwork for the development of a biological substitute for bladder tissue that can support storage of urine and restore physiologic voiding. Although many researchers have been able to demonstrate the formation of engineered tissue with a structure similar to that of native bladder tissue, restoration of physiologic voiding using these constructs has never been demonstrated. The main issues hindering the development of larger contractile tissues that allow physiologic voiding include the development of correct muscle alignment, proper innervation and vascularization. Conclusion: Tissue engineering of a construct that will support the contractile properties that allow physiologic voiding is a complex process. The combination of smart scaffolds with controlled topography, the ability to deliver multiple trophic factors and an optimal cell source will allow for the engineering of functional bladder tissues in the near future.",
keywords = "Bioengineering, Functional bladder tissue, Innervation, Scaffolds, Vascularization",
author = "Maya Horst and Srinivas Madduri and Rita Gobet and Tullio Sulser and Vinzent Milleret and Heike Hall and Anthony Atala and Daniel Eberli",
year = "2013",
month = "7",
day = "1",
doi = "10.1002/term.547",
language = "English",
volume = "7",
pages = "515--522",
journal = "Journal of Tissue Engineering and Regenerative Medicine",
issn = "1932-6254",
publisher = "John Wiley and Sons Ltd",
number = "7",

}

TY - JOUR

T1 - Engineering functional bladder tissues

AU - Horst, Maya

AU - Madduri, Srinivas

AU - Gobet, Rita

AU - Sulser, Tullio

AU - Milleret, Vinzent

AU - Hall, Heike

AU - Atala, Anthony

AU - Eberli, Daniel

PY - 2013/7/1

Y1 - 2013/7/1

N2 - Purpose: End stage bladder disease can seriously affect patient quality of life and often requires surgical reconstruction with bowel tissue, which is associated with numerous complications. Bioengineering of functional bladder tissue using tissue-engineering techniques could provide new functional tissues for reconstruction. In this review, we discuss the current state of this field and address different approaches to enable physiologic voiding in engineered bladder tissues in the near future. Materials and Methods: In a collaborative effort, we gathered researchers from four institutions to discuss the current state of functional bladder engineering. A MEDLINE® and PubMed® search was conducted for articles related to tissue engineering of the bladder, with special focus on the cells and biomaterials employed as well as the microenvironment, vascularisation and innervation strategies used. Results: Over the last decade, advances in tissue engineering technology have laid the groundwork for the development of a biological substitute for bladder tissue that can support storage of urine and restore physiologic voiding. Although many researchers have been able to demonstrate the formation of engineered tissue with a structure similar to that of native bladder tissue, restoration of physiologic voiding using these constructs has never been demonstrated. The main issues hindering the development of larger contractile tissues that allow physiologic voiding include the development of correct muscle alignment, proper innervation and vascularization. Conclusion: Tissue engineering of a construct that will support the contractile properties that allow physiologic voiding is a complex process. The combination of smart scaffolds with controlled topography, the ability to deliver multiple trophic factors and an optimal cell source will allow for the engineering of functional bladder tissues in the near future.

AB - Purpose: End stage bladder disease can seriously affect patient quality of life and often requires surgical reconstruction with bowel tissue, which is associated with numerous complications. Bioengineering of functional bladder tissue using tissue-engineering techniques could provide new functional tissues for reconstruction. In this review, we discuss the current state of this field and address different approaches to enable physiologic voiding in engineered bladder tissues in the near future. Materials and Methods: In a collaborative effort, we gathered researchers from four institutions to discuss the current state of functional bladder engineering. A MEDLINE® and PubMed® search was conducted for articles related to tissue engineering of the bladder, with special focus on the cells and biomaterials employed as well as the microenvironment, vascularisation and innervation strategies used. Results: Over the last decade, advances in tissue engineering technology have laid the groundwork for the development of a biological substitute for bladder tissue that can support storage of urine and restore physiologic voiding. Although many researchers have been able to demonstrate the formation of engineered tissue with a structure similar to that of native bladder tissue, restoration of physiologic voiding using these constructs has never been demonstrated. The main issues hindering the development of larger contractile tissues that allow physiologic voiding include the development of correct muscle alignment, proper innervation and vascularization. Conclusion: Tissue engineering of a construct that will support the contractile properties that allow physiologic voiding is a complex process. The combination of smart scaffolds with controlled topography, the ability to deliver multiple trophic factors and an optimal cell source will allow for the engineering of functional bladder tissues in the near future.

KW - Bioengineering

KW - Functional bladder tissue

KW - Innervation

KW - Scaffolds

KW - Vascularization

UR - http://www.scopus.com/inward/record.url?scp=84879553816&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879553816&partnerID=8YFLogxK

U2 - 10.1002/term.547

DO - 10.1002/term.547

M3 - Article

C2 - 22438261

AN - SCOPUS:84879553816

VL - 7

SP - 515

EP - 522

JO - Journal of Tissue Engineering and Regenerative Medicine

JF - Journal of Tissue Engineering and Regenerative Medicine

SN - 1932-6254

IS - 7

ER -