Engineering antigen-specific immunological tolerance

Stephan Kontos, Alizée J. Grimm, Jeffrey A. Hubbell

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Unwanted immunity develops in response to many protein drugs, in autoimmunity, in allergy, and in transplantation. Approaches to induce immunological tolerance aim to either prevent these responses or reverse them after they have already taken place. We present here recent developments in approaches, based on engineered peptides, proteins and biomaterials, that harness mechanisms of peripheral tolerance both prophylactically and therapeutically to induce antigen-specific immunological tolerance. These mechanisms are based on responses of B and T lymphocytes to other cells in their immune environment that result in cellular deletion or ignorance to particular antigens, or in development of active immune regulatory responses. Several of these approaches are moving toward clinical development, and some are already in early stages of clinical testing.

Original languageEnglish (US)
Pages (from-to)80-88
Number of pages9
JournalCurrent Opinion in Immunology
Volume35
DOIs
StatePublished - Aug 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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