Engineering a novel microphysiological system to recapitulate biologic barrier functions

Matthew Ishahak, Quratulain Amin, Jordan Hill, Adiel Hernandez, Laura Wubker, Siddarth Rawal, Alessia Fornoni, Ashutosh Agarwal

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Despite the widespread use of PDMS for microfluidic applications, its adsorption of small molecules has created a hinderance to the adoption of microphysiological systems (MPS). Previously, our group has demonstrated the feasibility of developing MPS from biocompatible poly(methyl methacrylate) (PMMA). Here, we have expanded our approach to develop a novel microfluidic chip with both an apical and basal flow channel and incorporated pressure-driven pumps to recapitulate the glomerular filtration barrier and lung alveolus.

Original languageEnglish (US)
Title of host publication23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
PublisherChemical and Biological Microsystems Society
Pages448-449
Number of pages2
ISBN (Electronic)9781733419000
StatePublished - 2019
Event23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, Switzerland
Duration: Oct 27 2019Oct 31 2019

Publication series

Name23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

Conference

Conference23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
CountrySwitzerland
CityBasel
Period10/27/1910/31/19

Keywords

  • Kidney-on-chip
  • Lung-on-chip
  • Microfluidics
  • Microphysiological System

ASJC Scopus subject areas

  • Bioengineering
  • Chemical Engineering (miscellaneous)

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