Endurance exercise is protective for mice with mitochondrial myopathy

Tina Wenz, Francisca Diaz, Dayami Hernandez, Carlos T Moraes

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Defects in the mitochondrial ATP-generating system are one of the most commonly inherited neurological disorders, but they remain without treatment. We have recently shown that modulation of the peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) level in skeletal muscle of a mitochondrial myopathy mouse model offers a therapeutic approach. Here we analyzed if endurance exercise, which is known to be associated with an increased PGC-1α level in muscle, offers the same beneficial effect. We subjected male and female mice that develop a severe mitochondrial myopathy due to a cytochrome-c oxidase deficiency at 3 mo of age to endurance exercise training and monitored phenotypical and metabolic changes. Sedentary myopathy and wildtype mice were used as controls. Exercise increased PGC-1α in muscle, resulting in increased mitochondrial biogenesis, and successfully stimulated residual respiratory capacity in muscle tissue. As a consequence, ATP levels were increased in exercised mice compared with sedentary myopathy animals, which resulted in a delayed onset of the myopathy and a prolonged lifespan of the exercised mice. As an added benefit, endurance exercise induced antioxidant enzymes. The overall protective effect of endurance exercise delayed the onset of the mitochondrial myopathy and increased life expectancy in the mouse model. Thus stimulating residual oxidative phosphorylation function in the affected muscle by inducing mitochondrial biogenesis through endurance exercise might offer a valuable therapeutic intervention for mitochondrial myopathy patients.

Original languageEnglish
Pages (from-to)1712-1719
Number of pages8
JournalJournal of Applied Physiology
Volume106
Issue number5
DOIs
StatePublished - May 1 2009

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Mitochondrial Myopathies
Exercise
Muscular Diseases
Muscles
Organelle Biogenesis
Cytochrome-c Oxidase Deficiency
Adenosine Triphosphate
Peroxisome Proliferator-Activated Receptors
Oxidative Phosphorylation
Life Expectancy
Nervous System Diseases
Skeletal Muscle
Therapeutics
Antioxidants
Enzymes

Keywords

  • Mitochondrial biogenesis
  • Mitochondrial diseases

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Endurance exercise is protective for mice with mitochondrial myopathy. / Wenz, Tina; Diaz, Francisca; Hernandez, Dayami; Moraes, Carlos T.

In: Journal of Applied Physiology, Vol. 106, No. 5, 01.05.2009, p. 1712-1719.

Research output: Contribution to journalArticle

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