Endothelium-derived relaxing factor, nitric oxide: Effects on and production by mesangial cells and the glomerulus

Leopoldo Raij, Pamela J. Shultz

Research output: Contribution to journalReview article

66 Scopus citations

Abstract

The endothelium-derived relaxing factor nitric oxide (EDRF/NO) is a labile, endogenous vasodilator that is important in the control of systemic vascular tone. This review focuses on the effects of EDRF/NO on glomerular mesangial cells in vitro and on the role of EDRF/NO in mesangial and glomerular physiology and pathophysiology in vivo. It was concluded that EDRF/NO can stimulate increases in cGMP, inhibit mesangial cell contraction, and inhibit growth factor-induced proliferation of mesangial cells in culture. Furthermore, incubation with endotoxin or cytokines stimulates mesangial cells to produce EDRF/ NO, via an inducible NO synthase enzyme. Therefore, it is likely that NO could play a role in the inflammatory response within the glomerulus. Finally, recent studies providing evidence that EDRF/NO is functional within the glomerulus in vivo, especially during endotoxemia and inflammation are also reviewed.

Original languageEnglish (US)
Pages (from-to)1435-1441
Number of pages7
JournalJournal of the American Society of Nephrology
Volume3
Issue number8
StatePublished - Feb 1 1993

Keywords

  • Cell contraction
  • Cell proliferation
  • cGMP
  • Cytokines
  • Endotoxin
  • Nitrate
  • Nitrite

ASJC Scopus subject areas

  • Nephrology

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