Endothelium-derived relaxing factor, nitric oxide

Effects on and production by mesangial cells and the glomerulus

Leopoldo Raij, Pamela J. Shultz

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

The endothelium-derived relaxing factor nitric oxide (EDRF/NO) is a labile, endogenous vasodilator that is important in the control of systemic vascular tone. This review focuses on the effects of EDRF/NO on glomerular mesangial cells in vitro and on the role of EDRF/NO in mesangial and glomerular physiology and pathophysiology in vivo. It was concluded that EDRF/NO can stimulate increases in cGMP, inhibit mesangial cell contraction, and inhibit growth factor-induced proliferation of mesangial cells in culture. Furthermore, incubation with endotoxin or cytokines stimulates mesangial cells to produce EDRF/ NO, via an inducible NO synthase enzyme. Therefore, it is likely that NO could play a role in the inflammatory response within the glomerulus. Finally, recent studies providing evidence that EDRF/NO is functional within the glomerulus in vivo, especially during endotoxemia and inflammation are also reviewed.

Original languageEnglish
Pages (from-to)1435-1441
Number of pages7
JournalJournal of the American Society of Nephrology
Volume3
Issue number8
StatePublished - Feb 1 1993
Externally publishedYes

Fingerprint

Endothelium-Dependent Relaxing Factors
Mesangial Cells
Nitric Oxide
Endotoxemia
Vasodilator Agents
Endotoxins
Nitric Oxide Synthase
Blood Vessels
Intercellular Signaling Peptides and Proteins
Cell Culture Techniques
Cytokines
Inflammation
Enzymes

Keywords

  • Cell contraction
  • Cell proliferation
  • cGMP
  • Cytokines
  • Endotoxin
  • Nitrate
  • Nitrite

ASJC Scopus subject areas

  • Nephrology

Cite this

Endothelium-derived relaxing factor, nitric oxide : Effects on and production by mesangial cells and the glomerulus. / Raij, Leopoldo; Shultz, Pamela J.

In: Journal of the American Society of Nephrology, Vol. 3, No. 8, 01.02.1993, p. 1435-1441.

Research output: Contribution to journalArticle

@article{f14eac2bfbd44693aa54111b3aa94933,
title = "Endothelium-derived relaxing factor, nitric oxide: Effects on and production by mesangial cells and the glomerulus",
abstract = "The endothelium-derived relaxing factor nitric oxide (EDRF/NO) is a labile, endogenous vasodilator that is important in the control of systemic vascular tone. This review focuses on the effects of EDRF/NO on glomerular mesangial cells in vitro and on the role of EDRF/NO in mesangial and glomerular physiology and pathophysiology in vivo. It was concluded that EDRF/NO can stimulate increases in cGMP, inhibit mesangial cell contraction, and inhibit growth factor-induced proliferation of mesangial cells in culture. Furthermore, incubation with endotoxin or cytokines stimulates mesangial cells to produce EDRF/ NO, via an inducible NO synthase enzyme. Therefore, it is likely that NO could play a role in the inflammatory response within the glomerulus. Finally, recent studies providing evidence that EDRF/NO is functional within the glomerulus in vivo, especially during endotoxemia and inflammation are also reviewed.",
keywords = "Cell contraction, Cell proliferation, cGMP, Cytokines, Endotoxin, Nitrate, Nitrite",
author = "Leopoldo Raij and Shultz, {Pamela J.}",
year = "1993",
month = "2",
day = "1",
language = "English",
volume = "3",
pages = "1435--1441",
journal = "Journal of the American Society of Nephrology",
issn = "1046-6673",
publisher = "American Society of Nephrology",
number = "8",

}

TY - JOUR

T1 - Endothelium-derived relaxing factor, nitric oxide

T2 - Effects on and production by mesangial cells and the glomerulus

AU - Raij, Leopoldo

AU - Shultz, Pamela J.

PY - 1993/2/1

Y1 - 1993/2/1

N2 - The endothelium-derived relaxing factor nitric oxide (EDRF/NO) is a labile, endogenous vasodilator that is important in the control of systemic vascular tone. This review focuses on the effects of EDRF/NO on glomerular mesangial cells in vitro and on the role of EDRF/NO in mesangial and glomerular physiology and pathophysiology in vivo. It was concluded that EDRF/NO can stimulate increases in cGMP, inhibit mesangial cell contraction, and inhibit growth factor-induced proliferation of mesangial cells in culture. Furthermore, incubation with endotoxin or cytokines stimulates mesangial cells to produce EDRF/ NO, via an inducible NO synthase enzyme. Therefore, it is likely that NO could play a role in the inflammatory response within the glomerulus. Finally, recent studies providing evidence that EDRF/NO is functional within the glomerulus in vivo, especially during endotoxemia and inflammation are also reviewed.

AB - The endothelium-derived relaxing factor nitric oxide (EDRF/NO) is a labile, endogenous vasodilator that is important in the control of systemic vascular tone. This review focuses on the effects of EDRF/NO on glomerular mesangial cells in vitro and on the role of EDRF/NO in mesangial and glomerular physiology and pathophysiology in vivo. It was concluded that EDRF/NO can stimulate increases in cGMP, inhibit mesangial cell contraction, and inhibit growth factor-induced proliferation of mesangial cells in culture. Furthermore, incubation with endotoxin or cytokines stimulates mesangial cells to produce EDRF/ NO, via an inducible NO synthase enzyme. Therefore, it is likely that NO could play a role in the inflammatory response within the glomerulus. Finally, recent studies providing evidence that EDRF/NO is functional within the glomerulus in vivo, especially during endotoxemia and inflammation are also reviewed.

KW - Cell contraction

KW - Cell proliferation

KW - cGMP

KW - Cytokines

KW - Endotoxin

KW - Nitrate

KW - Nitrite

UR - http://www.scopus.com/inward/record.url?scp=0027547167&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027547167&partnerID=8YFLogxK

M3 - Article

VL - 3

SP - 1435

EP - 1441

JO - Journal of the American Society of Nephrology

JF - Journal of the American Society of Nephrology

SN - 1046-6673

IS - 8

ER -