Pannexin1 is ubiquitously expressed in vertebrate tissues, but the role it plays in vascular tone regulation remains unclear. We found that Pannexin1 expression level is much higher in the endothelium relative to smooth muscle of saphenous artery. The ability of endothelium-intact arteries for dilation was significantly impaired whereas contractile responses were considerably increased in mice with genetic ablation of Pannexin1. No such increased contractile responses were detected in the endothelium-denuded arteries. Combined, our findings suggest a new function of Pannexin1 as an important player in normal endothelium-dependent regulation of arterial tone, where it facilitates vessel dilation and attenuates constriction. Reviewed by Dr. Armen Mulkidjanian and Dr. Alexander Lobkovsky.
- Knockout mice
- Saphenous artery
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Applied Mathematics
- Modeling and Simulation
- Ecology, Evolution, Behavior and Systematics
Endothelial function is impaired in conduit arteries of pannexin1 knockout mice. / Gaynullina, Dina; Tarasova, Olga S.; Kiryukhina, Oxana O.; Shestopalov, Valery I; Panchin, Yuri.In: Biology Direct, Vol. 9, No. 1, 8, 17.05.2014.
Research output: Contribution to journal › Article