Endothelial function is impaired in conduit arteries of pannexin1 knockout mice

Dina Gaynullina, Olga S. Tarasova, Oxana O. Kiryukhina, Valery I Shestopalov, Yuri Panchin

12 Scopus citations

Abstract

Pannexin1 is ubiquitously expressed in vertebrate tissues, but the role it plays in vascular tone regulation remains unclear. We found that Pannexin1 expression level is much higher in the endothelium relative to smooth muscle of saphenous artery. The ability of endothelium-intact arteries for dilation was significantly impaired whereas contractile responses were considerably increased in mice with genetic ablation of Pannexin1. No such increased contractile responses were detected in the endothelium-denuded arteries. Combined, our findings suggest a new function of Pannexin1 as an important player in normal endothelium-dependent regulation of arterial tone, where it facilitates vessel dilation and attenuates constriction. Reviewed by Dr. Armen Mulkidjanian and Dr. Alexander Lobkovsky.

Original languageEnglish
Article number8
JournalBiology Direct
Volume9
Issue number1
DOIs
StatePublished - May 17 2014

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Keywords

  • Endothelium
  • Knockout mice
  • Pannexin1
  • Saphenous artery

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology
  • Applied Mathematics
  • Modeling and Simulation
  • Ecology, Evolution, Behavior and Systematics

Cite this

Endothelial function is impaired in conduit arteries of pannexin1 knockout mice. / Gaynullina, Dina; Tarasova, Olga S.; Kiryukhina, Oxana O.; Shestopalov, Valery I; Panchin, Yuri.

In: Biology Direct, Vol. 9, No. 1, 8, 17.05.2014.

Research output: Contribution to journalArticle