Endothelial cell functions. Relationship to atherogenesis

M. Toborek, S. Kaiser

Research output: Contribution to journalReview articlepeer-review

82 Scopus citations

Abstract

The vascular endothelium plays a critical role in the preservation of normal vessel wall structure and function. In particular, endothelial cells control vascular permeability, vessel tone, coagulation, fibrinolysis, and inflammatory responses. These functions are accomplished by production of a variety of biologically active substances. However, endothelial cell-mediated reactions may also lead to the development of pathological stages within the vessel wall. The current review is focused on endothelial cell metabolism in relationship to the development of atherosclerosis.

Original languageEnglish (US)
Pages (from-to)295-314
Number of pages20
JournalBasic Research in Cardiology
Volume94
Issue number5
DOIs
StatePublished - Oct 1 1999
Externally publishedYes

Keywords

  • Coagulation, fibrinolysis
  • Endothelial permeability
  • Vascular inflammatory response
  • Vascular tone

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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