Endothelial-astrocytic interactions in acute liver failure

A. R. Jayakumar, M. D. Norenberg

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Brain edema and the subsequent increase in intracranial pressure are major neurological complications of acute liver failure (ALF), and swelling of astrocytes (cytotoxic brain edema) is the most prominent neuropathological abnormality in ALF. Recent studies, however, have suggested the co-existence of cytotoxic and vasogenic mechanisms in the brain edema associated with ALF. This review 1) summarizes the nature of the brain edema in humans and experimental animals with ALF; 2) reviews in vitro studies supporting the presence of cytotoxic brain edema (cell swelling in cultured astrocytes); and 3) documents the role of brain endothelial cells in the development of astrocyte swelling/brain edema in ALF.

Original languageEnglish (US)
Pages (from-to)183-186
Number of pages4
JournalMetabolic Brain Disease
Issue number2
StatePublished - Jun 2013


  • Acute liver failure
  • Astrocytes
  • Blood-brain barrier
  • Brain edema
  • Endothelial cells
  • Hepatic encephalopathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Biochemistry
  • Cellular and Molecular Neuroscience

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