Endoscopic and surgiacl management of primary sclerosing cholangitis

Anthony Michaels, Cynthia Levy

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Primary sclerosing cholangitis (PSC) is a rare, chronic cholestatic liver disease of uncertain etiology characterized by the destruction of the intrahepatic and extrahepatic bile ducts through inflammation and fibrosis. This development of inflammation and fibrosis leads to biliary complications including cirrhosis and ultimately death. Given the uncertainty surrounding the pathogenesis of the disease, many different medical therapies have been studied in the treatment of PSC. However, there currently are no effective medical therapies known to halt progression of disease. Additionally, patients with PSC often develop symptoms and complications that can be managed endoscopically or surgically. This review primarily focuses on endoscopic and surgical approaches that have been studied in the treatment of patients with PSC.

Original languageEnglish
Article number242
JournalMedGenMed Medscape General Medicine
Volume10
Issue number10
StatePublished - Nov 17 2008
Externally publishedYes

Fingerprint

Sclerosing Cholangitis
Fibrosis
Inflammation
Intrahepatic Bile Ducts
Extrahepatic Bile Ducts
Therapeutics
Uncertainty
Disease Progression
Liver Diseases

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Endoscopic and surgiacl management of primary sclerosing cholangitis. / Michaels, Anthony; Levy, Cynthia.

In: MedGenMed Medscape General Medicine, Vol. 10, No. 10, 242, 17.11.2008.

Research output: Contribution to journalArticle

@article{53a0302e2fec42bca8081607222a4f9e,
title = "Endoscopic and surgiacl management of primary sclerosing cholangitis",
abstract = "Primary sclerosing cholangitis (PSC) is a rare, chronic cholestatic liver disease of uncertain etiology characterized by the destruction of the intrahepatic and extrahepatic bile ducts through inflammation and fibrosis. This development of inflammation and fibrosis leads to biliary complications including cirrhosis and ultimately death. Given the uncertainty surrounding the pathogenesis of the disease, many different medical therapies have been studied in the treatment of PSC. However, there currently are no effective medical therapies known to halt progression of disease. Additionally, patients with PSC often develop symptoms and complications that can be managed endoscopically or surgically. This review primarily focuses on endoscopic and surgical approaches that have been studied in the treatment of patients with PSC.",
author = "Anthony Michaels and Cynthia Levy",
year = "2008",
month = "11",
day = "17",
language = "English",
volume = "10",
journal = "MedGenMed Medscape General Medicine",
issn = "1531-0132",
publisher = "Medscape Health Network",
number = "10",

}

TY - JOUR

T1 - Endoscopic and surgiacl management of primary sclerosing cholangitis

AU - Michaels, Anthony

AU - Levy, Cynthia

PY - 2008/11/17

Y1 - 2008/11/17

N2 - Primary sclerosing cholangitis (PSC) is a rare, chronic cholestatic liver disease of uncertain etiology characterized by the destruction of the intrahepatic and extrahepatic bile ducts through inflammation and fibrosis. This development of inflammation and fibrosis leads to biliary complications including cirrhosis and ultimately death. Given the uncertainty surrounding the pathogenesis of the disease, many different medical therapies have been studied in the treatment of PSC. However, there currently are no effective medical therapies known to halt progression of disease. Additionally, patients with PSC often develop symptoms and complications that can be managed endoscopically or surgically. This review primarily focuses on endoscopic and surgical approaches that have been studied in the treatment of patients with PSC.

AB - Primary sclerosing cholangitis (PSC) is a rare, chronic cholestatic liver disease of uncertain etiology characterized by the destruction of the intrahepatic and extrahepatic bile ducts through inflammation and fibrosis. This development of inflammation and fibrosis leads to biliary complications including cirrhosis and ultimately death. Given the uncertainty surrounding the pathogenesis of the disease, many different medical therapies have been studied in the treatment of PSC. However, there currently are no effective medical therapies known to halt progression of disease. Additionally, patients with PSC often develop symptoms and complications that can be managed endoscopically or surgically. This review primarily focuses on endoscopic and surgical approaches that have been studied in the treatment of patients with PSC.

UR - http://www.scopus.com/inward/record.url?scp=55849087571&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=55849087571&partnerID=8YFLogxK

M3 - Article

C2 - 19099036

AN - SCOPUS:55849087571

VL - 10

JO - MedGenMed Medscape General Medicine

JF - MedGenMed Medscape General Medicine

SN - 1531-0132

IS - 10

M1 - 242

ER -