Endoscopic and surgiacl management of primary sclerosing cholangitis

Anthony Michaels, Cynthia Levy

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Primary sclerosing cholangitis (PSC) is a rare, chronic cholestatic liver disease of uncertain etiology characterized by the destruction of the intrahepatic and extrahepatic bile ducts through inflammation and fibrosis. This development of inflammation and fibrosis leads to biliary complications including cirrhosis and ultimately death. Given the uncertainty surrounding the pathogenesis of the disease, many different medical therapies have been studied in the treatment of PSC. However, there currently are no effective medical therapies known to halt progression of disease. Additionally, patients with PSC often develop symptoms and complications that can be managed endoscopically or surgically. This review primarily focuses on endoscopic and surgical approaches that have been studied in the treatment of patients with PSC.

Original languageEnglish (US)
Article number242
JournalMedGenMed Medscape General Medicine
Volume10
Issue number10
StatePublished - Nov 17 2008
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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