Endoreduplication and telomeric association in a choroid plexus carcinoma

You S. Li, Yao Shan Fan, Ross F. Armstrong

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Cytogenetic studies showed a hyperhaploid stemline, (32,XY,+1,+7,+9,+12,+13,+14,+19,+20) in a patient with choroid plexus carcinoma. Endoreduplication and doubling of the stemline to 200-400 chromosomes per cell and variation in numerical changes were also noted. Telomeric association was present in most cells. The 12p and 20q were by far the most frequently involved chromosome arms. Telomeric association is believed to have triggered further structural changes in this case since the 12p and 20q were always involved in the few structural abnormalities identified. A review of the literature suggests that hyperhaploidy may characterize choroid plexus carcinoma and hyperdiploidy choroid plexus papilloma.

Original languageEnglish (US)
Pages (from-to)7-10
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume87
Issue number1
DOIs
StatePublished - Mar 1996
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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