Endoplasmic reticulum–mitochondria crosstalk: from junction to function across neurological disorders

Pabbala Veeresh, Harpreet Kaur, Deepaneeta Sarmah, Leela Mounica, Geetesh Verma, Vignesh Kotian, Radhika Kesharwani, Kiran Kalia, Anupom Borah, Xin Wang, Kunjan R. Dave, Anne Marie Rodriguez, Dileep R. Yavagal, Pallab Bhattacharya

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

The endoplasmic reticulum (ER) and mitochondria are fundamental organelles highly interconnected with a specialized set of proteins in cells. ER–mitochondrial interconnections form specific microdomains, called mitochondria-associated ER membranes, that have been found to play important roles in calcium signaling and lipid homeostasis, and more recently in mitochondrial dynamics, inflammation, and autophagy. It is not surprising that perturbations in ER–mitochondria connections can result in the progression of disease, especially neurological disorders; hence, their architecture and regulation are crucial in determining the fate of cells and disease. The molecular identity of the specialized proteins regulating ER–mitochondrial crosstalk remains unclear. Our discussion here describes the physical and functional crosstalk between these two dynamic organelles and emphasizes the outcome of altered ER–mitochondrial interconnections in neurological disorders.

Original languageEnglish (US)
Pages (from-to)41-60
Number of pages20
JournalAnnals of the New York Academy of Sciences
Volume1457
Issue number1
DOIs
StatePublished - Dec 1 2019

Keywords

  • Alzheimer's disease
  • ERMES
  • Huntington's disease
  • MAMs
  • Parkinson's disease
  • amyotrophic lateral sclerosis
  • cerebral ischemia

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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