Abstract
PURPOSE:: To report the clinical presentation, antibiotic sensitivities, treatment strategies, and visual outcomes associated with endophthalmitis caused by Klebsiella species. METHODS:: A noncomparative consecutive case series. Microbiology database records were retrospectively reviewed for all patients with endophthalmitis caused by Klebsiella species from 1990 to 2012 at a large university referral center. The corresponding clinical records were then reviewed to evaluate the endophthalmitis clinical features and treatment outcomes. RESULTS:: Seven patients were identified. Clinical settings included endogenous (n = 3), posttraumatic (n = 2), trabeculectomy bleb-associated (n = 1), and postpenetrating keratoplasty (n = 1). Five patients presented with hypopyon. Presenting visual acuity ranged from 20/60 to light perception in nonendogenous cases and 1/200 to light perception in endogenous cases. Klebsiella was sensitive to aminoglycosides, third-generation cephalosporins, and second- and third-generation fluoroquinolones in all cases. Initial treatment strategies were vitreous tap and injection (n = 4), pars plana vitrectomy with intravitreal antibiotics (n = 2), and anterior chamber tap and injection (n = 1). All three endogenous cases later underwent enucleation or evisceration. In nonendogenous cases, the final visual acuity was 20/70 or better in all 4 patients. CONCLUSION:: Endophthalmitis caused by Klebsiella species is associated with poor visual outcomes. Endogenous cases had high rates of enucleation or evisceration.
| Original language | English |
|---|---|
| Pages (from-to) | 1875-1881 |
| Number of pages | 7 |
| Journal | Retina |
| Volume | 34 |
| Issue number | 9 |
| DOIs | |
| State | Published - Jan 1 2014 |
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Keywords
- Bacterial eye infections
- Endogenous
- Endophthalmitis
- Klebsiella
ASJC Scopus subject areas
- Ophthalmology
Cite this
Endophthalmitis caused by Klebsiella species. / Sridhar, Jayanth; Flynn, Harry W; Kuriyan, Ajay; Dubovy, Sander; Miller, Darlene.
In: Retina, Vol. 34, No. 9, 01.01.2014, p. 1875-1881.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Endophthalmitis caused by Klebsiella species
AU - Sridhar, Jayanth
AU - Flynn, Harry W
AU - Kuriyan, Ajay
AU - Dubovy, Sander
AU - Miller, Darlene
PY - 2014/1/1
Y1 - 2014/1/1
N2 - PURPOSE:: To report the clinical presentation, antibiotic sensitivities, treatment strategies, and visual outcomes associated with endophthalmitis caused by Klebsiella species. METHODS:: A noncomparative consecutive case series. Microbiology database records were retrospectively reviewed for all patients with endophthalmitis caused by Klebsiella species from 1990 to 2012 at a large university referral center. The corresponding clinical records were then reviewed to evaluate the endophthalmitis clinical features and treatment outcomes. RESULTS:: Seven patients were identified. Clinical settings included endogenous (n = 3), posttraumatic (n = 2), trabeculectomy bleb-associated (n = 1), and postpenetrating keratoplasty (n = 1). Five patients presented with hypopyon. Presenting visual acuity ranged from 20/60 to light perception in nonendogenous cases and 1/200 to light perception in endogenous cases. Klebsiella was sensitive to aminoglycosides, third-generation cephalosporins, and second- and third-generation fluoroquinolones in all cases. Initial treatment strategies were vitreous tap and injection (n = 4), pars plana vitrectomy with intravitreal antibiotics (n = 2), and anterior chamber tap and injection (n = 1). All three endogenous cases later underwent enucleation or evisceration. In nonendogenous cases, the final visual acuity was 20/70 or better in all 4 patients. CONCLUSION:: Endophthalmitis caused by Klebsiella species is associated with poor visual outcomes. Endogenous cases had high rates of enucleation or evisceration.
AB - PURPOSE:: To report the clinical presentation, antibiotic sensitivities, treatment strategies, and visual outcomes associated with endophthalmitis caused by Klebsiella species. METHODS:: A noncomparative consecutive case series. Microbiology database records were retrospectively reviewed for all patients with endophthalmitis caused by Klebsiella species from 1990 to 2012 at a large university referral center. The corresponding clinical records were then reviewed to evaluate the endophthalmitis clinical features and treatment outcomes. RESULTS:: Seven patients were identified. Clinical settings included endogenous (n = 3), posttraumatic (n = 2), trabeculectomy bleb-associated (n = 1), and postpenetrating keratoplasty (n = 1). Five patients presented with hypopyon. Presenting visual acuity ranged from 20/60 to light perception in nonendogenous cases and 1/200 to light perception in endogenous cases. Klebsiella was sensitive to aminoglycosides, third-generation cephalosporins, and second- and third-generation fluoroquinolones in all cases. Initial treatment strategies were vitreous tap and injection (n = 4), pars plana vitrectomy with intravitreal antibiotics (n = 2), and anterior chamber tap and injection (n = 1). All three endogenous cases later underwent enucleation or evisceration. In nonendogenous cases, the final visual acuity was 20/70 or better in all 4 patients. CONCLUSION:: Endophthalmitis caused by Klebsiella species is associated with poor visual outcomes. Endogenous cases had high rates of enucleation or evisceration.
KW - Bacterial eye infections
KW - Endogenous
KW - Endophthalmitis
KW - Klebsiella
UR - http://www.scopus.com/inward/record.url?scp=84906937338&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84906937338&partnerID=8YFLogxK
U2 - 10.1097/IAE.0000000000000162
DO - 10.1097/IAE.0000000000000162
M3 - Article
C2 - 24801652
AN - SCOPUS:84906937338
VL - 34
SP - 1875
EP - 1881
JO - Retina
JF - Retina
SN - 0275-004X
IS - 9
ER -