Endogenous phosphorylation in dunning prostate tumors of rats treated with LH‐RH analogues

Georges Cehovic; Tommie W. Redding; Marion T. Hierowski; Andrew V. Schally

doi:10.1002/pros.2990050606

Endogenous phosphorylation in dunning prostate tumors of rats treated with LH‐RH analogues

Georges Cehovic, Tommie W. Redding, Marion T. Hierowski, Andrew V. Schally

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The authors investigated phosphorylation in Dunning R-3327H prostate tumor tissue of untreated rats, and rats treated with the agonist D-Trp⁶-LH-RH and antagonist N-Ac-D-p-Cl-Phe(1,2),D-Trp³,D-Arg⁶,D-Ala¹⁰-LH-RH. The total phosphorylation was significantly higher in Dunning tumors than in normal ventral and dorsal prostate. Incorporation of ³²P into tumor tissue of rats treated with D-Trp⁶-LH-RH was significantly lower than in tumors from untreated animals. The tumor regression produced by LH-RH agonist appeared to be linked with changes in the pattern of tumor protein phosphorylation. Although inhibition of tumor growth also occurred after administration of the LH-RH antagonist, no significant changes in phosphorylation were observed. The dissimilarity of effects of the agonists and the antagonists on protein phosphorylation in rat prostate tumors may be related to the differences in the mechanisms of action of these two types of LH-RH analogues.

Original language	English (US)
Pages (from-to)	605-611
Number of pages	7
Journal	The Prostate
Volume	5
Issue number	6
DOIs	https://doi.org/10.1002/pros.2990050606
State	Published - 1984
Externally published	Yes

Keywords

Dunning prostate tumor
LH‐RH analogues
P incorporation

ASJC Scopus subject areas

Oncology
Urology

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title = "Endogenous phosphorylation in dunning prostate tumors of rats treated with LH‐RH analogues",

abstract = "The authors investigated phosphorylation in Dunning R-3327H prostate tumor tissue of untreated rats, and rats treated with the agonist D-Trp6-LH-RH and antagonist N-Ac-D-p-Cl-Phe(1,2),D-Trp3,D-Arg6,D-Ala10-LH-RH. The total phosphorylation was significantly higher in Dunning tumors than in normal ventral and dorsal prostate. Incorporation of 32P into tumor tissue of rats treated with D-Trp6-LH-RH was significantly lower than in tumors from untreated animals. The tumor regression produced by LH-RH agonist appeared to be linked with changes in the pattern of tumor protein phosphorylation. Although inhibition of tumor growth also occurred after administration of the LH-RH antagonist, no significant changes in phosphorylation were observed. The dissimilarity of effects of the agonists and the antagonists on protein phosphorylation in rat prostate tumors may be related to the differences in the mechanisms of action of these two types of LH-RH analogues.",

keywords = "Dunning prostate tumor, LH‐RH analogues, P incorporation",

author = "Georges Cehovic and Redding, {Tommie W.} and Hierowski, {Marion T.} and Schally, {Andrew V.}",

year = "1984",

doi = "10.1002/pros.2990050606",

language = "English (US)",

volume = "5",

pages = "605--611",

journal = "Prostate",

issn = "0270-4137",

publisher = "Wiley-Liss Inc.",

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T1 - Endogenous phosphorylation in dunning prostate tumors of rats treated with LH‐RH analogues

AU - Cehovic, Georges

AU - Redding, Tommie W.

AU - Hierowski, Marion T.

AU - Schally, Andrew V.

PY - 1984

Y1 - 1984

N2 - The authors investigated phosphorylation in Dunning R-3327H prostate tumor tissue of untreated rats, and rats treated with the agonist D-Trp6-LH-RH and antagonist N-Ac-D-p-Cl-Phe(1,2),D-Trp3,D-Arg6,D-Ala10-LH-RH. The total phosphorylation was significantly higher in Dunning tumors than in normal ventral and dorsal prostate. Incorporation of 32P into tumor tissue of rats treated with D-Trp6-LH-RH was significantly lower than in tumors from untreated animals. The tumor regression produced by LH-RH agonist appeared to be linked with changes in the pattern of tumor protein phosphorylation. Although inhibition of tumor growth also occurred after administration of the LH-RH antagonist, no significant changes in phosphorylation were observed. The dissimilarity of effects of the agonists and the antagonists on protein phosphorylation in rat prostate tumors may be related to the differences in the mechanisms of action of these two types of LH-RH analogues.

AB - The authors investigated phosphorylation in Dunning R-3327H prostate tumor tissue of untreated rats, and rats treated with the agonist D-Trp6-LH-RH and antagonist N-Ac-D-p-Cl-Phe(1,2),D-Trp3,D-Arg6,D-Ala10-LH-RH. The total phosphorylation was significantly higher in Dunning tumors than in normal ventral and dorsal prostate. Incorporation of 32P into tumor tissue of rats treated with D-Trp6-LH-RH was significantly lower than in tumors from untreated animals. The tumor regression produced by LH-RH agonist appeared to be linked with changes in the pattern of tumor protein phosphorylation. Although inhibition of tumor growth also occurred after administration of the LH-RH antagonist, no significant changes in phosphorylation were observed. The dissimilarity of effects of the agonists and the antagonists on protein phosphorylation in rat prostate tumors may be related to the differences in the mechanisms of action of these two types of LH-RH analogues.

KW - Dunning prostate tumor

KW - LH‐RH analogues

KW - P incorporation

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