Endogenous nitric oxide synthase inhibitors, arterial hemodynamics, and subclinical vascular disease

The PREVENCION study

Julio A. Chirinos, Robert David, J. Alexander Bralley, Humberto Zea-Díaz, Edgar Muñoz-Atahualpa, Fernando Corrales-Medina, Carolina Cuba-Bustinza, Julio Chirinos-Pacheco, Josefina Medina-Lezama

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Endogenous NO synthase inhibitors (end-NOSIs) have been associated with cardiovascular risk factors and atherosclerosis. In addition, end-NOSIs may directly cause hypertension through hemodynamic effects. We aimed to examine the association between end-NOSI asymmetrical dimethylarginine (ADMA) and N-guanidino-monomethyl-arginine (NMMA), subclinical atherosclerosis, and arterial hemodynamics. We studied 922 adults participating in a population-based study (PREVENCION Study) and examined the correlation between end-NOSI/L-arginine and arterial hemodynamics, carotid-femoral pulse wave velocity, and carotid intima-media thickness using linear regression. ADMA, NMMA, and L-arginine were found to be differentially associated with various classic cardiovascular risk factors. ADMA and NMMA (but not L-arginine) were significant predictors of carotid intima-media thickness, even after adjustment for cardiovascular risk factors, C-reactive protein, and renal function. In contrast, ADMA and NMMA did not predict carotid-femoral pulse wave velocity, blood pressure, or hemodynamic abnormalities. Higher L-arginine independently predicted systolic hypertension, higher central pulse pressure, incident wave amplitude, central augmented pressure, and lower total arterial compliance but not systemic vascular resistance or cardiac output. We conclude that ADMA and NMMA are differentially associated with cardiovascular risk factors, but both end-NOSIs are independent predictors of carotid atherosclerosis. In contrast, they are not associated with large artery stiffness, hypertension, or hemodynamic abnormalities. Our findings are consistent with a role for asymmetrical arginine methylation in atherosclerosis but not in large artery stiffening, hypertension, or long-term hemodynamic regulation. L-Arginine is independently associated with abnormal pulsatile (but not resistive) arterial hemodynamic indices, which may reflect abnormal L-arginine transport, leading to decreased intracellular bioavailability for NO synthesis.

Original languageEnglish (US)
Pages (from-to)1051-1059
Number of pages9
JournalHypertension
Volume52
Issue number6
DOIs
StatePublished - Dec 2008
Externally publishedYes

Fingerprint

Vascular Diseases
Nitric Oxide Synthase
Arginine
Hemodynamics
Hypertension
Atherosclerosis
Carotid Intima-Media Thickness
Pulse Wave Analysis
Thigh
Arteries
Blood Pressure
Carotid Artery Diseases
Cardiac Output
Vascular Resistance
C-Reactive Protein
Methylation
Biological Availability
Compliance
Linear Models
dimethylarginine

Keywords

  • Arterial stiffness
  • Asymmetrical dimethylarginine
  • Atherosclerosis
  • Hemodynamics
  • Hypertension

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Endogenous nitric oxide synthase inhibitors, arterial hemodynamics, and subclinical vascular disease : The PREVENCION study. / Chirinos, Julio A.; David, Robert; Bralley, J. Alexander; Zea-Díaz, Humberto; Muñoz-Atahualpa, Edgar; Corrales-Medina, Fernando; Cuba-Bustinza, Carolina; Chirinos-Pacheco, Julio; Medina-Lezama, Josefina.

In: Hypertension, Vol. 52, No. 6, 12.2008, p. 1051-1059.

Research output: Contribution to journalArticle

Chirinos, JA, David, R, Bralley, JA, Zea-Díaz, H, Muñoz-Atahualpa, E, Corrales-Medina, F, Cuba-Bustinza, C, Chirinos-Pacheco, J & Medina-Lezama, J 2008, 'Endogenous nitric oxide synthase inhibitors, arterial hemodynamics, and subclinical vascular disease: The PREVENCION study', Hypertension, vol. 52, no. 6, pp. 1051-1059. https://doi.org/10.1161/HYPERTENSIONAHA.108.120352
Chirinos, Julio A. ; David, Robert ; Bralley, J. Alexander ; Zea-Díaz, Humberto ; Muñoz-Atahualpa, Edgar ; Corrales-Medina, Fernando ; Cuba-Bustinza, Carolina ; Chirinos-Pacheco, Julio ; Medina-Lezama, Josefina. / Endogenous nitric oxide synthase inhibitors, arterial hemodynamics, and subclinical vascular disease : The PREVENCION study. In: Hypertension. 2008 ; Vol. 52, No. 6. pp. 1051-1059.
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