Adult neurogenesis in the central nervous system (CNS) is a distinctive process that leads to the renewal of neuronal populations in brain regions such as the olfactory bulb and hippocampal dentate gyrus. The existence of self-renewing, migratory neural stem/progenitor cells (NSPCs) in the adult brain has led to discoveries about their homeostatic role in neurogenesis and injury-induced changes following CNS trauma. Expansion and ectopic migration of quiescent endogenous NSPCs is thought to stabilize the injured milieu with the potential of providing cellular replacement of damaged or lost neurons. A better understanding of how resident NSPCs are robustly activated as well as limited will provide a way forward for maximizing the potential of these cells to reconstitute the cellular architecture in an attempt to regain function after injury. Here, we will focus specifically on traumatic brain injury and its effects on the neurogenic compartments in the adult brain and the subsequent responses.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)