Abstract
Eight consecutive cases of culture-proven endogenous Candida endophthalmitis (ECE) were managed between 1980 and 1988. All patients were treated with vitrectomy and injection of intravitreal amphotericin B. Blood cultures were negative in all patients, although Candida albicans was cultured from a foot ulcer in one patient. No systemic therapy was used in three patients, three patients received oral ketoconazole, and two patients received oral flucytosine postoperatively. Intravenous amphotericin B was not used because of lack of evidence of disseminated candidiasis and the systemic toxicity associated with its use. The ECE responded favorably to treatment in all cases. Final vision was better in patients with a shorter interval between onset of symptoms and initiation of antifungal therapy. Posttreatment visual acuities were: four eyes ≥ 20/50, two eyes at 20/80 to 20/200, and two eyes < 5/200. This series showed that ECE without evidence of disseminated disease can be treated successfully with vitrectomy and intravitreal amphotericin B.
| Original language | English |
|---|---|
| Pages (from-to) | 666-674 |
| Number of pages | 9 |
| Journal | Ophthalmology |
| Volume | 97 |
| Issue number | 5 |
| State | Published - Jan 1 1990 |
Fingerprint
ASJC Scopus subject areas
- Ophthalmology
Cite this
Endogenous Candida endophthalmitis. Management without intravenous amphotericin B. / Brod, R. D.; Flynn, Harry W; Clarkson, J. G.; Pflugfelder, S. C.; Culbertson, William W; Miller, Darlene.
In: Ophthalmology, Vol. 97, No. 5, 01.01.1990, p. 666-674.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Endogenous Candida endophthalmitis. Management without intravenous amphotericin B
AU - Brod, R. D.
AU - Flynn, Harry W
AU - Clarkson, J. G.
AU - Pflugfelder, S. C.
AU - Culbertson, William W
AU - Miller, Darlene
PY - 1990/1/1
Y1 - 1990/1/1
N2 - Eight consecutive cases of culture-proven endogenous Candida endophthalmitis (ECE) were managed between 1980 and 1988. All patients were treated with vitrectomy and injection of intravitreal amphotericin B. Blood cultures were negative in all patients, although Candida albicans was cultured from a foot ulcer in one patient. No systemic therapy was used in three patients, three patients received oral ketoconazole, and two patients received oral flucytosine postoperatively. Intravenous amphotericin B was not used because of lack of evidence of disseminated candidiasis and the systemic toxicity associated with its use. The ECE responded favorably to treatment in all cases. Final vision was better in patients with a shorter interval between onset of symptoms and initiation of antifungal therapy. Posttreatment visual acuities were: four eyes ≥ 20/50, two eyes at 20/80 to 20/200, and two eyes < 5/200. This series showed that ECE without evidence of disseminated disease can be treated successfully with vitrectomy and intravitreal amphotericin B.
AB - Eight consecutive cases of culture-proven endogenous Candida endophthalmitis (ECE) were managed between 1980 and 1988. All patients were treated with vitrectomy and injection of intravitreal amphotericin B. Blood cultures were negative in all patients, although Candida albicans was cultured from a foot ulcer in one patient. No systemic therapy was used in three patients, three patients received oral ketoconazole, and two patients received oral flucytosine postoperatively. Intravenous amphotericin B was not used because of lack of evidence of disseminated candidiasis and the systemic toxicity associated with its use. The ECE responded favorably to treatment in all cases. Final vision was better in patients with a shorter interval between onset of symptoms and initiation of antifungal therapy. Posttreatment visual acuities were: four eyes ≥ 20/50, two eyes at 20/80 to 20/200, and two eyes < 5/200. This series showed that ECE without evidence of disseminated disease can be treated successfully with vitrectomy and intravitreal amphotericin B.
UR - http://www.scopus.com/inward/record.url?scp=0025275963&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025275963&partnerID=8YFLogxK
M3 - Article
C2 - 2188195
AN - SCOPUS:0025275963
VL - 97
SP - 666
EP - 674
JO - Ophthalmology
JF - Ophthalmology
SN - 0161-6420
IS - 5
ER -