TY - JOUR
T1 - Endogenous bacterial retinitis in aids
AU - Davis, Janet L.
AU - Nussenblatt, Robert B.
AU - Bachman, David M.
AU - Chan, Chi Chao
AU - Palestine, Alan G.
PY - 1989/6/15
Y1 - 1989/6/15
N2 - We studied two patients, one with histologically confirmed endogenous bacterial retinitis associated with the acquired immunodeficiency syndrome and a second with ophthalmoscopically identical findings who also responded to antibiotic treatment. Both patients had focal, discrete patches of retinitis that enlarged slowly over weeks and ultimately accumulated large amounts of subretinal fluid and retinal exudate. One patient underwent retinal biopsy after systemic and vitreous cultures were negative. Histopathologic sections showed necrotic retina infiltrated with multiple histiocytes containing intracytoplasmic, iodine-positive, pleomorphic, encapsulated bacterial forms. The organism was not grown from the retinal biopsy specimen. Treatment with antibiotics resulted in improved vision in both patients. Our results indicate that endogenous bacterial infection should be considered in the differential diagnosis of retinitis associated with the acquired immunodeficiency syndrome.
AB - We studied two patients, one with histologically confirmed endogenous bacterial retinitis associated with the acquired immunodeficiency syndrome and a second with ophthalmoscopically identical findings who also responded to antibiotic treatment. Both patients had focal, discrete patches of retinitis that enlarged slowly over weeks and ultimately accumulated large amounts of subretinal fluid and retinal exudate. One patient underwent retinal biopsy after systemic and vitreous cultures were negative. Histopathologic sections showed necrotic retina infiltrated with multiple histiocytes containing intracytoplasmic, iodine-positive, pleomorphic, encapsulated bacterial forms. The organism was not grown from the retinal biopsy specimen. Treatment with antibiotics resulted in improved vision in both patients. Our results indicate that endogenous bacterial infection should be considered in the differential diagnosis of retinitis associated with the acquired immunodeficiency syndrome.
UR - http://www.scopus.com/inward/record.url?scp=0024403340&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024403340&partnerID=8YFLogxK
U2 - 10.1016/0002-9394(89)90258-4
DO - 10.1016/0002-9394(89)90258-4
M3 - Article
C2 - 2658616
AN - SCOPUS:0024403340
VL - 107
SP - 613
EP - 623
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
IS - 6
ER -