Endogenous bacterial retinitis in aids

Janet L. Davis, Robert B. Nussenblatt, David M. Bachman, Chi Chao Chan, Alan G. Palestine

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


We studied two patients, one with histologically confirmed endogenous bacterial retinitis associated with the acquired immunodeficiency syndrome and a second with ophthalmoscopically identical findings who also responded to antibiotic treatment. Both patients had focal, discrete patches of retinitis that enlarged slowly over weeks and ultimately accumulated large amounts of subretinal fluid and retinal exudate. One patient underwent retinal biopsy after systemic and vitreous cultures were negative. Histopathologic sections showed necrotic retina infiltrated with multiple histiocytes containing intracytoplasmic, iodine-positive, pleomorphic, encapsulated bacterial forms. The organism was not grown from the retinal biopsy specimen. Treatment with antibiotics resulted in improved vision in both patients. Our results indicate that endogenous bacterial infection should be considered in the differential diagnosis of retinitis associated with the acquired immunodeficiency syndrome.

Original languageEnglish (US)
Pages (from-to)613-623
Number of pages11
JournalAmerican journal of ophthalmology
Issue number6
StatePublished - Jun 15 1989
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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