Endocrine manipulation of the Dunning prostatic adenocarcinoma

F. S. Shessel, N. L. Block, B. Stover, A. Claflin, T. I. Malinin, V. A. Politano

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


The Dunning animal model was used to evaluate endocrine management of prostatic adenocarcinoma. Hypophysectomy, alone or in combination, and orchiectomy plus stilbestrol were the most effective means of suppressing tumor growth. Medical adrenalectomy by aminoglutethimide administration was as effective as surgical ablation. Accessary organ weights bore no direct relationship to the inhibition of tumor growth.

Original languageEnglish (US)
Pages (from-to)529-533
Number of pages5
JournalInvestigative Urology
Issue number6
StatePublished - Jul 11 1980

ASJC Scopus subject areas

  • Medicine(all)


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