Endocrine controls of primary adult human stem cell biology: Thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro

S. Tiede, K. Bohm, N. Meier, W. Funk, R. Paus

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Here we demonstrate that physiological concentrations of the thyroid hormones T3 and T4 enhance the KERATIN 15 promoter activity and expression in epithelial stem cells of adult human scalp hair follicles in situ and in vitro. Additionally, T3 and T4 stimulate expression of the immuno-inhibitory surface molecule CD200. Subsequently, T3 and T4 induce apoptosis and differentiation and inhibit clonal growth of these progenitor cells in vitro. These data suggest that human hair follicle bulge-derived epithelial stem cells underlie profound, previously unknown hormonal regulation by thyroid hormones, and show that primary human keratin 15-GFP+ progenitor cells can be exploited to further elucidate fundamental endocrine controls of human epithelial stem cells.

Original languageEnglish (US)
Pages (from-to)769-777
Number of pages9
JournalEuropean Journal of Cell Biology
Volume89
Issue number10
DOIs
StatePublished - Oct 2010

Keywords

  • Adult
  • CD200
  • Epithelial hair follicle stem cells
  • Human
  • Keratin 15
  • Thyroid hormones

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

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