Endocarditis associated with antineutrophil cytoplasmic antibodies: A case report and review of the literature

Julio A. Chirinos, Vicente F. Corrales-Medina, Santiago Garcia, Daniel M. Lichtstein, Alan L. Bisno, Simon C Chakko

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

We report a case of subacute bacterial endocarditis associated with small vessel vasculitis and a strongly positive cytoplasmic antineutrophil cytoplasmic antibody (c-ANCA) test. It is important to recognize this cause of positive c-ANCA because infectious endocarditis may closely mimic the clinical manifestations of ANCA-associated vasculitides such as Wegener granulomatosis or microscopic polyangiitis. Furthermore, ANCA-associated vasculitis may result in noninfectious endocarditis, which may be confused with bacterial endocarditis. In this paper, we review reported cases of ANCA-positive bacterial endocarditis and compare them to the reported cases of ANCA-associated idiopathic vasculitis with endocardial compromise.

Original languageEnglish (US)
Pages (from-to)590-595
Number of pages6
JournalClinical Rheumatology
Volume26
Issue number4
DOIs
StatePublished - Apr 1 2007

Keywords

  • Antineutrophil cytoplasmic antibodies
  • Endocarditis
  • Wegener granulomatosis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

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