Endocapsular lavage with photofrin II as a photodynamic therapy for lens epithelial proliferation

J. M. Parel, R. Cubeddu, R. Ramponi, R. Lingua, C. A. Sacchi, E. Haefliger

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The most common and visually significant complication of both extracapsular and endocapsular cataract extractions is the formation of a secondary cataract because of the proliferation of retained lens epithelial cells. The intraocular distribution of Photofrin II uptake after endocapsular lensectomy and lavage has been quantified to evaluate the feasibility of photodynamic therapy to prevent proliferation. Intraocular distribution was determined by measuring the fluorescence decay curves in sections of eyes using a microspectrofluorometer with high spatial and temporal resolution. An equal affinity for lens epithelium, corneal endothelium, iris and ciliary body was noted. No significant uptake in the retina was detected. Evaluation of photodynamic therapy to prevent lens epithelial proliferation will require specific localization of the drug to lens epithelium.

Original languageEnglish (US)
Pages (from-to)25-30
Number of pages6
JournalLasers in medical science
Volume5
Issue number1
DOIs
StatePublished - Mar 1 1990

Keywords

  • Endocapsular surgery
  • Haematoporphyrin derivative
  • Phaco-Ersatz
  • Secondary cataract
  • Time-resolved fluorescence microscopy

ASJC Scopus subject areas

  • Surgery
  • Medicine (miscellaneous)

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