Encephalomyelitis Associated With Leukemia in a Child

Jocelyn B. Gregorios, Eneida Roldan, Joanna A Davis, Richard Curless

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A case of an encephalomyelitis in a child with acute lymphoblastic leukemia is reported. The patient was a 5-year-old boy who developed seizures, progressive confusion, and coma after radiation and intrathecal methotrexate therapy. Computed tomography (CT) of the brain showed bilateral hypodensities in the posterior parietal and temporal regions. At autopsy, perivascular inflammation, microglial nodules without intranuclear viral inclusions, and bilateral necrosis of the temporoparietal and hippocampal regions were seen in the brain and spinal cord. Paraneoplastic encephalomyelitis is generally recognized in adult patients with underlying malignancy but, to our knowledge, has not been reported in children with leukemia. This report should alert the clinicians to an entity that must be included in the differential diagnosis of leukemic children with progressive neurologic disorder. (J Child Neurol 1987;2:293-297).

Original languageEnglish (US)
Pages (from-to)293-297
Number of pages5
JournalJournal of Child Neurology
Volume2
Issue number4
DOIs
StatePublished - 1987

Fingerprint

Encephalomyelitis
Leukemia
Nervous System Paraneoplastic Syndromes
Intranuclear Inclusion Bodies
Parietal Lobe
Brain
Temporal Lobe
Coma
Nervous System Diseases
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Methotrexate
Autopsy
Spinal Cord
Seizures
Differential Diagnosis
Necrosis
Tomography
Radiation
Inflammation
Neoplasms

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Cite this

Gregorios, J. B., Roldan, E., Davis, J. A., & Curless, R. (1987). Encephalomyelitis Associated With Leukemia in a Child. Journal of Child Neurology, 2(4), 293-297. https://doi.org/10.1177/088307388700200411

Encephalomyelitis Associated With Leukemia in a Child. / Gregorios, Jocelyn B.; Roldan, Eneida; Davis, Joanna A; Curless, Richard.

In: Journal of Child Neurology, Vol. 2, No. 4, 1987, p. 293-297.

Research output: Contribution to journalArticle

Gregorios, JB, Roldan, E, Davis, JA & Curless, R 1987, 'Encephalomyelitis Associated With Leukemia in a Child', Journal of Child Neurology, vol. 2, no. 4, pp. 293-297. https://doi.org/10.1177/088307388700200411
Gregorios, Jocelyn B. ; Roldan, Eneida ; Davis, Joanna A ; Curless, Richard. / Encephalomyelitis Associated With Leukemia in a Child. In: Journal of Child Neurology. 1987 ; Vol. 2, No. 4. pp. 293-297.
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