TY - JOUR
T1 - En Face Optical Coherence Tomography Imaging for the Detection of Nascent Geographic Atrophy
AU - Schaal, Karen B.
AU - Gregori, Giovanni
AU - Rosenfeld, Philip J.
N1 - Funding Information:
Funding/Support: Research supported by a grant from Carl Zeiss Meditec Inc (Dublin, California), the Macula Vision Research Foundation, the National Eye Institute Center Core Grant (P30EY014801), an unrestricted grant from Research to Prevent Blindness, the Feig Family Foundation, and the Emma Clyde Hodge Memorial Foundation. Karen B. Schaal receives funding from a grant from the German Research Foundation (DFG), Bonn, Germany, (SCHA 1869/1-1). Financial Disclosures: Philip Rosenfeld and Giovanni Gregori received research support from Carl Zeiss Meditec, and Giovanni Gregori and the University of Miami co-own a patent that is licensed to Carl Zeiss Meditec. Philip Rosenfeld receives additional research support from Acucela, Apellis, Carl Zeiss Meditec, Genentech, GlaxoSmithKline, Neurotech, Ocata Therapeutics, and Tyrogenex. He is a consultant to Achillion Pharmaceuticals, Acucela, Alcon, Boehringer-Ingelheim, Cell Cure Neurosciences, Chengdu Kanghong Biotech, CoDa Therapeutics, Genentech, Healios K.K, F. Hoffmann-La Roche Ltd, MacRegen Inc, NGM Biopharmaceuticals, Ocata Therapeutics, Ocudyne, Regeneron, Stealth BioTherapeutics, Tyrogenex, and Vision Medicines. The following author has no financial disclosures: Karen B. Schaal. All authors attest that they meet the current ICMJE criteria for authorship.
Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Purpose To determine if en face optical coherence tomography (OCT) imaging can identify nascent geographic atrophy (nGA) in eyes with intermediate age-related macular degeneration (iAMD). Design Retrospective observational case series. Methods Patients with iAMD from the COMPLETE study at the Bascom Palmer Eye Institute were evaluated to determine if nGA was present at baseline and at follow-up using high-density Spectralis OCT B-scans and en face OCT images from the Cirrus OCT instrument. If available, additional en face OCT images and B-scans were analyzed at follow-up times beyond the 52-week period. Results A total of 37 eyes (27 patients) were evaluated for at least 1 year using both B-scans and en face images. Two drusen suspicious for nGA at baseline were identified, but neither druse developed GA after 24 and 62 months of follow-up, respectively. Another druse displayed hypertransmission into the choroid at week 52 on B-scan imaging and was classified as nGA. En face OCT imaging identified this druse as a focal bright area. Drusen breakdown occurred during a follow-up of 39 months. Conclusions En face OCT imaging appeared to be as useful as routine B-scan imaging for identifying areas suspicious for nGA in this population from the COMPLETE Study. Additional longitudinal follow-up of eyes with drusen is needed to determine if en face OCT imaging can replace the evaluation of individual B-scans for the detection of nGA.
AB - Purpose To determine if en face optical coherence tomography (OCT) imaging can identify nascent geographic atrophy (nGA) in eyes with intermediate age-related macular degeneration (iAMD). Design Retrospective observational case series. Methods Patients with iAMD from the COMPLETE study at the Bascom Palmer Eye Institute were evaluated to determine if nGA was present at baseline and at follow-up using high-density Spectralis OCT B-scans and en face OCT images from the Cirrus OCT instrument. If available, additional en face OCT images and B-scans were analyzed at follow-up times beyond the 52-week period. Results A total of 37 eyes (27 patients) were evaluated for at least 1 year using both B-scans and en face images. Two drusen suspicious for nGA at baseline were identified, but neither druse developed GA after 24 and 62 months of follow-up, respectively. Another druse displayed hypertransmission into the choroid at week 52 on B-scan imaging and was classified as nGA. En face OCT imaging identified this druse as a focal bright area. Drusen breakdown occurred during a follow-up of 39 months. Conclusions En face OCT imaging appeared to be as useful as routine B-scan imaging for identifying areas suspicious for nGA in this population from the COMPLETE Study. Additional longitudinal follow-up of eyes with drusen is needed to determine if en face OCT imaging can replace the evaluation of individual B-scans for the detection of nGA.
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U2 - 10.1016/j.ajo.2016.11.002
DO - 10.1016/j.ajo.2016.11.002
M3 - Article
C2 - 27864062
AN - SCOPUS:85004007036
VL - 174
SP - 145
EP - 154
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
ER -