Empirically treated Pneumocystis carinii pneumonia in Los Angeles, Chicago, and Miami: 1987-1990

Charles L. Bennett, Ronnie D. Horner, Robert A. Weinstein, Harold A. Kessler, Gordon Dickinson, David L. Pitrak, Stuart C. Gilman, W. Lance George, Susan E. Cohn, Michael S. Simberkoff, Jeffrey M. Jacobson, Jack A. DeHovitz, Matthew B. Goetz, Martin F. Shapiro

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Many patients infected with the human immunodeficiency virus (HIV) with symptoms suggestive of pneumonia are treated empirically for Pneumocystis carinii pneumonia (PCP), although other bacterial infections (e.g., tuberculosis) and pulmonary Kaposi's sarcoma may cause identical symptoms. Empiric treatment for PCP may result in misdiagnosis and mistreatment. When the outcomes of cytologically confirmed versus empirically treated PCP cases were evaluated, the most important predictors of in-hospital mortality were severity of illness and use of bronchoscopy. Persons who did not undergo bronchoscopy had higher mortality rates than patients negative by bronchoscopy or cytologically confirmed as positive for PCP (22% vs. 11% vs. 14%, P < .01), although severity of illness and timing of anti-PCP medications did not differ significantly. Compared with cytologically confirmed cases, persons who did not have bronchoscopy were more likely to die than were bronchoscopy-negative patients (P < .05), after adjusting for severity of illness. Bronchoscopy rise may have contributed to better outcomes for persons treated for HIV-related PCP.

Original languageEnglish
Pages (from-to)312-315
Number of pages4
JournalJournal of Infectious Diseases
Volume172
Issue number1
StatePublished - Jul 1 1995

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Pneumocystis Pneumonia
Los Angeles
Bronchoscopy
HIV
Kaposi's Sarcoma
Hospital Mortality
Diagnostic Errors
Pulmonary Tuberculosis
Bacterial Infections
Pneumonia
Mortality

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Bennett, C. L., Horner, R. D., Weinstein, R. A., Kessler, H. A., Dickinson, G., Pitrak, D. L., ... Shapiro, M. F. (1995). Empirically treated Pneumocystis carinii pneumonia in Los Angeles, Chicago, and Miami: 1987-1990. Journal of Infectious Diseases, 172(1), 312-315.

Empirically treated Pneumocystis carinii pneumonia in Los Angeles, Chicago, and Miami : 1987-1990. / Bennett, Charles L.; Horner, Ronnie D.; Weinstein, Robert A.; Kessler, Harold A.; Dickinson, Gordon; Pitrak, David L.; Gilman, Stuart C.; George, W. Lance; Cohn, Susan E.; Simberkoff, Michael S.; Jacobson, Jeffrey M.; DeHovitz, Jack A.; Goetz, Matthew B.; Shapiro, Martin F.

In: Journal of Infectious Diseases, Vol. 172, No. 1, 01.07.1995, p. 312-315.

Research output: Contribution to journalArticle

Bennett, CL, Horner, RD, Weinstein, RA, Kessler, HA, Dickinson, G, Pitrak, DL, Gilman, SC, George, WL, Cohn, SE, Simberkoff, MS, Jacobson, JM, DeHovitz, JA, Goetz, MB & Shapiro, MF 1995, 'Empirically treated Pneumocystis carinii pneumonia in Los Angeles, Chicago, and Miami: 1987-1990', Journal of Infectious Diseases, vol. 172, no. 1, pp. 312-315.
Bennett CL, Horner RD, Weinstein RA, Kessler HA, Dickinson G, Pitrak DL et al. Empirically treated Pneumocystis carinii pneumonia in Los Angeles, Chicago, and Miami: 1987-1990. Journal of Infectious Diseases. 1995 Jul 1;172(1):312-315.
Bennett, Charles L. ; Horner, Ronnie D. ; Weinstein, Robert A. ; Kessler, Harold A. ; Dickinson, Gordon ; Pitrak, David L. ; Gilman, Stuart C. ; George, W. Lance ; Cohn, Susan E. ; Simberkoff, Michael S. ; Jacobson, Jeffrey M. ; DeHovitz, Jack A. ; Goetz, Matthew B. ; Shapiro, Martin F. / Empirically treated Pneumocystis carinii pneumonia in Los Angeles, Chicago, and Miami : 1987-1990. In: Journal of Infectious Diseases. 1995 ; Vol. 172, No. 1. pp. 312-315.
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