Emodin regulates glucose utilization by activating amp-activated protein kinase

Parkyong Song, Jong Hyun Kim, Jaewang Ghim, Jong Hyuk Yoon, Areum Lee, Yonghoon Kwon, Hyunjung Hyun, Hyo Youl Moon, Hueng Sik Choi, Per Olof Berggren, Pann Ghill Suh, Sung Ho Ryu

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Background: AMPK activation improves glucose tolerance and insulin sensitivity. Results: Emodin increases glucose uptake in skeletal muscle and lowers blood glucose levels via AMPK activation. Conclusion: Administration of emodin leads to increased glucose tolerance and insulin sensitivity in vivo. Significance: Our results highlight the potential value of emodin as a drug for the treatment of diabetes.

Original languageEnglish
Pages (from-to)5732-5742
Number of pages11
JournalJournal of Biological Chemistry
Volume288
Issue number8
DOIs
StatePublished - Feb 22 2013
Externally publishedYes

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Emodin
Protein Kinases
AMP-Activated Protein Kinases
Glucose
Insulin Resistance
Chemical activation
Insulin
Medical problems
Muscle
Blood Glucose
Skeletal Muscle
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Song, P., Kim, J. H., Ghim, J., Yoon, J. H., Lee, A., Kwon, Y., ... Ryu, S. H. (2013). Emodin regulates glucose utilization by activating amp-activated protein kinase. Journal of Biological Chemistry, 288(8), 5732-5742. https://doi.org/10.1074/jbc.M112.441477

Emodin regulates glucose utilization by activating amp-activated protein kinase. / Song, Parkyong; Kim, Jong Hyun; Ghim, Jaewang; Yoon, Jong Hyuk; Lee, Areum; Kwon, Yonghoon; Hyun, Hyunjung; Moon, Hyo Youl; Choi, Hueng Sik; Berggren, Per Olof; Suh, Pann Ghill; Ryu, Sung Ho.

In: Journal of Biological Chemistry, Vol. 288, No. 8, 22.02.2013, p. 5732-5742.

Research output: Contribution to journalArticle

Song, P, Kim, JH, Ghim, J, Yoon, JH, Lee, A, Kwon, Y, Hyun, H, Moon, HY, Choi, HS, Berggren, PO, Suh, PG & Ryu, SH 2013, 'Emodin regulates glucose utilization by activating amp-activated protein kinase', Journal of Biological Chemistry, vol. 288, no. 8, pp. 5732-5742. https://doi.org/10.1074/jbc.M112.441477
Song, Parkyong ; Kim, Jong Hyun ; Ghim, Jaewang ; Yoon, Jong Hyuk ; Lee, Areum ; Kwon, Yonghoon ; Hyun, Hyunjung ; Moon, Hyo Youl ; Choi, Hueng Sik ; Berggren, Per Olof ; Suh, Pann Ghill ; Ryu, Sung Ho. / Emodin regulates glucose utilization by activating amp-activated protein kinase. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 8. pp. 5732-5742.
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