Emodin regulates glucose utilization by activating amp-activated protein kinase

Parkyong Song; Jong Hyun Kim; Jaewang Ghim; Jong Hyuk Yoon; Areum Lee; Yonghoon Kwon; Hyunjung Hyun; Hyo Youl Moon; Hueng Sik Choi; Per Olof Berggren; Pann Ghill Suh; Sung Ho Ryu

doi:10.1074/jbc.M112.441477

Emodin regulates glucose utilization by activating amp-activated protein kinase

Parkyong Song, Jong Hyun Kim, Jaewang Ghim, Jong Hyuk Yoon, Areum Lee, Yonghoon Kwon, Hyunjung Hyun, Hyo Youl Moon, Hueng Sik Choi, Per Olof Berggren, Pann Ghill Suh, Sung Ho Ryu

Research output: Contribution to journal › Article

42 Scopus citations

Abstract

Background: AMPK activation improves glucose tolerance and insulin sensitivity. Results: Emodin increases glucose uptake in skeletal muscle and lowers blood glucose levels via AMPK activation. Conclusion: Administration of emodin leads to increased glucose tolerance and insulin sensitivity in vivo. Significance: Our results highlight the potential value of emodin as a drug for the treatment of diabetes.

Original language	English
Pages (from-to)	5732-5742
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	288
Issue number	8
DOIs	https://doi.org/10.1074/jbc.M112.441477
State	Published - Feb 22 2013
Externally published	Yes

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ASJC Scopus subject areas

Biochemistry
Cell Biology
Molecular Biology

Cite this

Song, P., Kim, J. H., Ghim, J., Yoon, J. H., Lee, A., Kwon, Y., Hyun, H., Moon, H. Y., Choi, H. S., Berggren, P. O., Suh, P. G., & Ryu, S. H. (2013). Emodin regulates glucose utilization by activating amp-activated protein kinase. Journal of Biological Chemistry, 288(8), 5732-5742. https://doi.org/10.1074/jbc.M112.441477

Emodin regulates glucose utilization by activating amp-activated protein kinase. / Song, Parkyong; Kim, Jong Hyun; Ghim, Jaewang; Yoon, Jong Hyuk; Lee, Areum; Kwon, Yonghoon; Hyun, Hyunjung; Moon, Hyo Youl; Choi, Hueng Sik; Berggren, Per Olof; Suh, Pann Ghill; Ryu, Sung Ho.

In: Journal of Biological Chemistry, Vol. 288, No. 8, 22.02.2013, p. 5732-5742.

Research output: Contribution to journal › Article

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author = "Parkyong Song and Kim, {Jong Hyun} and Jaewang Ghim and Yoon, {Jong Hyuk} and Areum Lee and Yonghoon Kwon and Hyunjung Hyun and Moon, {Hyo Youl} and Choi, {Hueng Sik} and Berggren, {Per Olof} and Suh, {Pann Ghill} and Ryu, {Sung Ho}",

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10.1074/jbc.M112.441477