Emodin regulates glucose utilization by activating amp-activated protein kinase

Parkyong Song, Jong Hyun Kim, Jaewang Ghim, Jong Hyuk Yoon, Areum Lee, Yonghoon Kwon, Hyunjung Hyun, Hyo Youl Moon, Hueng Sik Choi, Per Olof Berggren, Pann Ghill Suh, Sung Ho Ryu

Research output: Contribution to journalArticle

42 Scopus citations


Background: AMPK activation improves glucose tolerance and insulin sensitivity. Results: Emodin increases glucose uptake in skeletal muscle and lowers blood glucose levels via AMPK activation. Conclusion: Administration of emodin leads to increased glucose tolerance and insulin sensitivity in vivo. Significance: Our results highlight the potential value of emodin as a drug for the treatment of diabetes.

Original languageEnglish
Pages (from-to)5732-5742
Number of pages11
JournalJournal of Biological Chemistry
Issue number8
StatePublished - Feb 22 2013
Externally publishedYes


ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Song, P., Kim, J. H., Ghim, J., Yoon, J. H., Lee, A., Kwon, Y., Hyun, H., Moon, H. Y., Choi, H. S., Berggren, P. O., Suh, P. G., & Ryu, S. H. (2013). Emodin regulates glucose utilization by activating amp-activated protein kinase. Journal of Biological Chemistry, 288(8), 5732-5742. https://doi.org/10.1074/jbc.M112.441477