Emerging treatments for depression

Paul E. Holtzheimer, Charles Nemeroff

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Established treatments for depression are often effective. However, a significant number of patients show limited or no response. With advancements in the explanation of the underlying neurobiology of depression, several novel therapeutic approaches have been developed. Emerging drug targets include novel monoamine oxidase inhibitors, triple monoamine re-uptake inhibitors, omega-3 fatty acids, melatoninergic agonists and receptor antagonists for corticotropin-releasing factor1, glucocorticoid, substance-P and NMDA. Developments in therapeutic focal brain stimulation include vagus nerve stimulation, transcranial magnetic stimulation, magnetic seizure therapy and deep brain stimulation. The role of psychotherapy, both as monotherapy and as adjunctive therapy, is an active avenue of investigation. Although data on these treatments are limited, preliminary results are encouraging. A major goal that remains to be achieved is the identification of predictors of response to the various antidepressant treatments that have diverse mechanisms of action.

Original languageEnglish
Pages (from-to)2323-2339
Number of pages17
JournalExpert Opinion on Pharmacotherapy
Volume7
Issue number17
DOIs
StatePublished - Dec 1 2006
Externally publishedYes

Fingerprint

Depression
Therapeutics
Corticotropin Receptors
Vagus Nerve Stimulation
Deep Brain Stimulation
Monoamine Oxidase Inhibitors
Neurobiology
Transcranial Magnetic Stimulation
Omega-3 Fatty Acids
N-Methylaspartate
Substance P
Psychotherapy
Antidepressive Agents
Glucocorticoids
Seizures
Brain
Pharmaceutical Preparations

Keywords

  • Antidepressant treatment
  • Depression
  • Focal brain stimulation
  • Neuropsychopharmacology

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Emerging treatments for depression. / Holtzheimer, Paul E.; Nemeroff, Charles.

In: Expert Opinion on Pharmacotherapy, Vol. 7, No. 17, 01.12.2006, p. 2323-2339.

Research output: Contribution to journalArticle

Holtzheimer, Paul E. ; Nemeroff, Charles. / Emerging treatments for depression. In: Expert Opinion on Pharmacotherapy. 2006 ; Vol. 7, No. 17. pp. 2323-2339.
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