Emerging therapeutics for ocular surface disease

Brett P. Bielory, Steven P. Shah, Terrence P. O'Brien, Victor L. Perez, Leonard Bielory

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Purpose of review The present review provides an overview on the potential of different systemic and topical treatments in chronic forms of ocular allergy and dry eye disorder (DED). The impact on anterior surface of ocular inflammatory disorder encompasses an array of conditions, which are frequently underreported. This can contribute to underdiagnoses and ineffective management from healthcare providers such as an allergist and/or ophthalmologist who routinely provide care for these common disorders. Owing to the current limited therapeutic options, healthcare providers are routinely seeking alternative treatments that could facilitate effective management of the conditions. Recent findings Recent advances in immunopathophysiology of ocular surface disorders has provided new potential targets and therapeutic strategies for the treatment of DED and ocular allergy that may include various immunobiological modulators. These modulators have focused on regulating the Th1 and Th2 immunemediated inflammatory pathways that inhibit various cytokines (e.g. IL-1, IL-4, IL-5, IL-9, IL-13) antibodies (e.g. IgE), and other surface markers of various cell lines (e.g. activated T-lymphocytes, lymphocyte function-associated antigen-1). Summary Recent findings about the pathophysiology of DED and ocular allergy have led to the greater understanding of the molecular and cellular mechanisms of ocular surface diseases leading to the potential novel targets for immunomodulation of anterior surface ocular disorders. New topical glucocorticoids, leukotriene receptor antagonists, IL-1 antagonists, IL-5, IL-4/IL-13 antagonists, integrin antagonists, and quinolone derivatives appear to be encouraging.

Original languageEnglish (US)
Pages (from-to)477-486
Number of pages10
JournalCurrent Opinion in Allergy and Clinical Immunology
Volume16
Issue number5
DOIs
StatePublished - Jan 1 2016

Keywords

  • Allergic conjunctivitis
  • dry eye disease
  • ocular allergy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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