Emerging roles of the single EF-hand Ca2+ sensor tescalcin in the regulation of gene expression, cell growth and differentiation

Ksenia G. Kolobynina, Valeria V. Solovyova, Konstantin Levay, Albert A. Rizvanov, Vladlen Z. Slepak

Research output: Contribution to journalComment/debate

9 Scopus citations

Abstract

Tescalcin (TESC, also known as calcineurin-homologous protein 3, CHP3) is a 24-kDa EF-hand Ca2+-binding protein that has recently emerged as a regulator of cell differentiation and growth. The TESC gene has also been linked to human brain abnormalities, and high expression of tescalcin has been found in several cancers. The expression level of tescalcin changes dramatically during development and upon signal-induced cell differentiation. Recent studies have shown that tescalcin is not only subjected to up- or down-regulation, but also has an active role in pathways that drive cell growth and differentiation programs. At the molecular level, there is compelling experimental evidence showing that tescalcin can directly interact with and regulate the activities of the Na+/H+ exchanger NHE1, subunit 4 of the COP9 signalosome (CSN4) and protein kinase glycogen-synthase kinase 3 (GSK3). In hematopoetic precursor cells, tescalcin has been shown to couple activation of the extracellular signal-regulated kinase (ERK) cascade to the expression of transcription factors that control cell differentiation. The purpose of thisCommentary is to summarize recent efforts that have served to characterize the biochemical, genetic and physiological attributes of tescalcin, and its unique role in the regulation of various cellular functions.

Original languageEnglish (US)
Pages (from-to)3533-3540
Number of pages8
JournalJournal of Cell Science
Volume129
Issue number19
DOIs
StatePublished - 2016

Keywords

  • CHP3
  • COP9
  • Differentiation
  • GSK3
  • NHE1
  • Tescalcin

ASJC Scopus subject areas

  • Cell Biology

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