Abstract
The serine-threonine kinase Akt also known as protein kinase B is one of the most studied molecules. In addition to the important role in carcinogenesis, Akt is a major regulator of carbohydrate metabolism. Akt mediates insulin-dependent glucose uptake in insulin-sensitive tissues. Recent evidence underscores the importance of Akt for regulation of β-cell mass and function. This review summarizes current findings concerning the molecular mechanisms, downstream signaling pathways, and critical components involved in regulation of β-cell mass and function by Akt. The results of these observations suggest that elucidation of critical downstream effectors of this signaling pathway could generate promising molecules as a potential target to induce proliferation and survival of β-cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 157-163 |
| Number of pages | 7 |
| Journal | International Journal of Biochemistry and Cell Biology |
| Volume | 38 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2006 |
| Externally published | Yes |
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Keywords
- β-Cell mass
- Akt
- Islets
- PKB
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
Cite this
Emerging role of protein kinase B/Akt signaling in pancreatic β-cell mass and function. / Elghazi, Lynda; Balcazar, Norman; Bernal Mizrachi, Ernesto.
In: International Journal of Biochemistry and Cell Biology, Vol. 38, No. 2, 02.2006, p. 157-163.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Emerging role of protein kinase B/Akt signaling in pancreatic β-cell mass and function
AU - Elghazi, Lynda
AU - Balcazar, Norman
AU - Bernal Mizrachi, Ernesto
PY - 2006/2
Y1 - 2006/2
N2 - The serine-threonine kinase Akt also known as protein kinase B is one of the most studied molecules. In addition to the important role in carcinogenesis, Akt is a major regulator of carbohydrate metabolism. Akt mediates insulin-dependent glucose uptake in insulin-sensitive tissues. Recent evidence underscores the importance of Akt for regulation of β-cell mass and function. This review summarizes current findings concerning the molecular mechanisms, downstream signaling pathways, and critical components involved in regulation of β-cell mass and function by Akt. The results of these observations suggest that elucidation of critical downstream effectors of this signaling pathway could generate promising molecules as a potential target to induce proliferation and survival of β-cells.
AB - The serine-threonine kinase Akt also known as protein kinase B is one of the most studied molecules. In addition to the important role in carcinogenesis, Akt is a major regulator of carbohydrate metabolism. Akt mediates insulin-dependent glucose uptake in insulin-sensitive tissues. Recent evidence underscores the importance of Akt for regulation of β-cell mass and function. This review summarizes current findings concerning the molecular mechanisms, downstream signaling pathways, and critical components involved in regulation of β-cell mass and function by Akt. The results of these observations suggest that elucidation of critical downstream effectors of this signaling pathway could generate promising molecules as a potential target to induce proliferation and survival of β-cells.
KW - β-Cell mass
KW - Akt
KW - Islets
KW - PKB
UR - http://www.scopus.com/inward/record.url?scp=27744540798&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27744540798&partnerID=8YFLogxK
U2 - 10.1016/j.biocel.2005.08.017
DO - 10.1016/j.biocel.2005.08.017
M3 - Article
C2 - 16213777
AN - SCOPUS:27744540798
VL - 38
SP - 157
EP - 163
JO - International Journal of Biochemistry and Cell Biology
JF - International Journal of Biochemistry and Cell Biology
SN - 1357-2725
IS - 2
ER -