Emerging role of protein kinase B/Akt signaling in pancreatic β-cell mass and function

Lynda Elghazi, Norman Balcazar, Ernesto Bernal-Mizrachi

Research output: Contribution to journalShort survey

42 Scopus citations

Abstract

The serine-threonine kinase Akt also known as protein kinase B is one of the most studied molecules. In addition to the important role in carcinogenesis, Akt is a major regulator of carbohydrate metabolism. Akt mediates insulin-dependent glucose uptake in insulin-sensitive tissues. Recent evidence underscores the importance of Akt for regulation of β-cell mass and function. This review summarizes current findings concerning the molecular mechanisms, downstream signaling pathways, and critical components involved in regulation of β-cell mass and function by Akt. The results of these observations suggest that elucidation of critical downstream effectors of this signaling pathway could generate promising molecules as a potential target to induce proliferation and survival of β-cells.

Original languageEnglish (US)
Pages (from-to)157-163
Number of pages7
JournalInternational Journal of Biochemistry and Cell Biology
Volume38
Issue number2
DOIs
StatePublished - Feb 2006
Externally publishedYes

Keywords

  • Akt
  • Islets
  • PKB
  • β-Cell mass

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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