Abstract
The serine-threonine kinase Akt also known as protein kinase B is one of the most studied molecules. In addition to the important role in carcinogenesis, Akt is a major regulator of carbohydrate metabolism. Akt mediates insulin-dependent glucose uptake in insulin-sensitive tissues. Recent evidence underscores the importance of Akt for regulation of β-cell mass and function. This review summarizes current findings concerning the molecular mechanisms, downstream signaling pathways, and critical components involved in regulation of β-cell mass and function by Akt. The results of these observations suggest that elucidation of critical downstream effectors of this signaling pathway could generate promising molecules as a potential target to induce proliferation and survival of β-cells.
Original language | English (US) |
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Pages (from-to) | 157-163 |
Number of pages | 7 |
Journal | International Journal of Biochemistry and Cell Biology |
Volume | 38 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2006 |
Externally published | Yes |
Keywords
- Akt
- Islets
- PKB
- β-Cell mass
ASJC Scopus subject areas
- Biochemistry
- Cell Biology