Emerging role for bone marrow derived mesenchymal stem cells in myocardial regenerative therapy

Jeffrey M. Zimmet, Joshua M. Hare

Research output: Contribution to journalArticle

120 Scopus citations

Abstract

Current treatments for ischemic cardiomyopathy are aimed toward minimizing the deleterious consequences of diseased myocardium. The possibility of treating heart failure by generating new myocardium and vascular tissue has been an impetus toward recent stem cell research. Mesenchymal stem cells (MSC), also referred to as marrow stromal cells, differentiate into a wide variety of lineages, including myocardial and endothelial cells. The multi-lineage potential of MSCs, their ability to elude detection by the host immune system, and their relative ease of expansion in culture make MSCs a very promising source of stem cells for transplantation. In addition, emerging experimental results with MSCs offer novel mechanistic insights into cardiac regenerative therapy in general. Here we review the characterization of MSCs, animal and human trials studying MSCs in cardiomyogenesis and vasculogenesis in postinfarct myocardium, routes of delivery, and potential mechanisms of stem cell repair.

Original languageEnglish (US)
Pages (from-to)471-481
Number of pages11
JournalBasic Research in Cardiology
Volume100
Issue number6
DOIs
StatePublished - Nov 1 2005
Externally publishedYes

Keywords

  • Cardiomyoplasty
  • Cytokines
  • Mesenchymal stem cells
  • Myocardial infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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