TY - JOUR
T1 - Emerging natural-product-based treatments for the management of osteoarthritis
AU - Pérez-Lozano, Maria Luisa
AU - Cesaro, Annabelle
AU - Mazor, Marija
AU - Esteve, Eric
AU - Berteina-Raboin, Sabine
AU - Best, Thomas M.
AU - Lespessailles, Eric
AU - Toumi, Hechmi
N1 - Funding Information:
This research was supported and funded by the FEDER (Fonds Europ?en pour le D?veloppement R?gional) dedicated to PRIMMO (Plateforme Recherche Innovation M?dicale Mutualis?e d?Orl?ans), the Orleans Mutualized Medical Innovation Research Platform for translational research.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/2
Y1 - 2021/2
N2 - Osteoarthritis (OA) is a complex degenerative disease in which joint homeostasis is disrupted, leading to synovial inflammation, cartilage degradation, subchondral bone remodeling, and resulting in pain and joint disability. Yet, the development of new treatment strategies to restore the equilibrium of the osteoarthritic joint remains a challenge. Numerous studies have revealed that dietary components and/or natural products have anti-inflammatory, antioxidant, anti-bone-resorption, and anabolic potential and have received much attention toward the development of new therapeutic strategies for OA treatment. In the present review, we provide an overview of current and emerging natural-product-based research treatments for OA management by drawing attention to experimental, pre-clinical, and clinical models. Herein, we review current and emerging natural-product-based research treatments for OA management.
AB - Osteoarthritis (OA) is a complex degenerative disease in which joint homeostasis is disrupted, leading to synovial inflammation, cartilage degradation, subchondral bone remodeling, and resulting in pain and joint disability. Yet, the development of new treatment strategies to restore the equilibrium of the osteoarthritic joint remains a challenge. Numerous studies have revealed that dietary components and/or natural products have anti-inflammatory, antioxidant, anti-bone-resorption, and anabolic potential and have received much attention toward the development of new therapeutic strategies for OA treatment. In the present review, we provide an overview of current and emerging natural-product-based research treatments for OA management by drawing attention to experimental, pre-clinical, and clinical models. Herein, we review current and emerging natural-product-based research treatments for OA management.
KW - Bone
KW - Cartilage
KW - Natural products
KW - Osteoarthritis
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U2 - 10.3390/antiox10020265
DO - 10.3390/antiox10020265
M3 - Review article
AN - SCOPUS:85100582816
VL - 10
SP - 1
EP - 27
JO - Antioxidants
JF - Antioxidants
SN - 2076-3921
IS - 2
M1 - 265
ER -