Emerging natural-product-based treatments for the management of osteoarthritis

Maria Luisa Pérez-Lozano, Annabelle Cesaro, Marija Mazor, Eric Esteve, Sabine Berteina-Raboin, Thomas M. Best, Eric Lespessailles, Hechmi Toumi

Research output: Contribution to journalReview articlepeer-review

Abstract

Osteoarthritis (OA) is a complex degenerative disease in which joint homeostasis is disrupted, leading to synovial inflammation, cartilage degradation, subchondral bone remodeling, and resulting in pain and joint disability. Yet, the development of new treatment strategies to restore the equilibrium of the osteoarthritic joint remains a challenge. Numerous studies have revealed that dietary components and/or natural products have anti-inflammatory, antioxidant, anti-bone-resorption, and anabolic potential and have received much attention toward the development of new therapeutic strategies for OA treatment. In the present review, we provide an overview of current and emerging natural-product-based research treatments for OA management by drawing attention to experimental, pre-clinical, and clinical models. Herein, we review current and emerging natural-product-based research treatments for OA management.

Original languageEnglish (US)
Article number265
Pages (from-to)1-27
Number of pages27
JournalAntioxidants
Volume10
Issue number2
DOIs
StatePublished - Feb 2021
Externally publishedYes

Keywords

  • Bone
  • Cartilage
  • Natural products
  • Osteoarthritis

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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