Emerging clinical applications of RNA

Bruce A. Sullenger, Eli Gilboa

Research output: Contribution to journalReview article

267 Scopus citations

Abstract

RNA is a versatile biological macromolecule that is crucial in mobilizing and interpreting our genetic information. It is not surprising then that researchers have sought to exploit the inherent properties of RNAs so as to interfere with or repair dysfunctional nucleic acids or proteins and to stimulate the production of therapeutic gene products in a variety of pathological situations. The first generation of the resulting RNA therapeutics are now being evaluated in clinical trials, raising significant interest in this emerging area of medical research.

Original languageEnglish (US)
Pages (from-to)252-258
Number of pages7
JournalNature
Volume418
Issue number6894
DOIs
StatePublished - Jul 11 2002

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