Emerging antidepressants to treat major depressive disorder

Samantha G. Block, Charles Nemeroff

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Depression is a common disorder with an annual risk of a depressive episode in the United States of 6.6%. Only 30-40% of patients remit with antidepressant monotherapy, leaving 60-70% of patients who do not optimally respond to therapy. Unremitted depressive patients are at increased risk for suicide. Considering the prevalence of treatment resistant depression and its consequences, treatment optimization is imperative. This review summarizes the latest treatment modalities for major depressive disorder including pharmacotherapy, electroconvulsive therapy, repetitive transcranial magnetic stimulation and psychotherapy. Through advancements in research to better understand the pathophysiology of depression, advances in treatment will be realized.

Original languageEnglish
Pages (from-to)7-16
Number of pages10
JournalAsian Journal of Psychiatry
Issue number1
StatePublished - 2014


  • Antidepressants
  • Major depressive disorder
  • Treatment

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)


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