Emergency Management of Seizures: An Overview

Basim M. Uthman, B. J. Wilder

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Summary: The drugs currently used in the emergency management of seizures are chiefly phenytoin, phenobarbital, diazepam, lorazepam, and paraldehyde. The combination of intravenous phenytoin and lorazepam has the advantages of rapid onset of action, sustained efficacy, and freedom from drug interactions. The intermittent oral or rectal administration of diazepam is especially useful for acute home treatment of recurrent seizures. Phenytoin prodrug (ACC‐9653), an investigational new drug, is promptly absorbed after intramuscular injection. Unlike phenytoin, it does not require propylene glycol and high alkalinity for solubility and therefore does not produce soft‐tissue injury after parenteral administration. It appears to be close to an ideal drug for the emergency management of seizures.

Original languageEnglish (US)
Pages (from-to)S33-S37
JournalEpilepsia
Volume30
DOIs
StatePublished - Jun 1989
Externally publishedYes

Keywords

  • Anticonvulsants
  • Diazepam
  • henytoin
  • Lorazepam
  • Paraldehyde
  • Phenobarbital
  • Phenytoin prodrug
  • Status epilepticus

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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