Emergence of cytotoxic T lymphocyte escape mutations in nonpathogenic simian immunodeficiency virus infection

Amitinder Kaur, Louis Alexander, Silvija I. Staprans, Lynn Denekamp, Corrina L. Hale, Harold M. McClure, Mark B. Feinberg, Ronald C. Desrosiers, R. Paul Johnson

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Although CTL escape has been well documented in pathogenic simian immunodeficiency virus (SIV) infection, there is no information on CTL escape in nonpathogenic SIV infection in nonhuman primate hosts like the sooty mangabeys. CTL responses and sequence variation in the SIV nef gene were evaluated in one sooty mangabey and one rhesus macaque inoculated together with the same stock of cloned SIVmac239. Each animal developed an immunodominant response to a distinct CTL epitope in Nef, aa 157-167 in the macaque and aa 20-28 in the mangabey. Nonsynonymous mutations in their respective epitopes were observed in both animals and resulted in loss of CTL recognition. These mutations were present in the majority of proviral DNA sequences at 16 weeks post infection in the macaque and >2 years post infection in the mangabey. These results document the occurrence of CTL escape in a host that does not develop AIDS, and adds to the growing body of evidence that CTL exert significant selective pressure in SIV infection.

Original languageEnglish (US)
Pages (from-to)3207-3217
Number of pages11
JournalEuropean Journal of Immunology
Volume31
Issue number11
DOIs
StatePublished - 2001

Keywords

  • CTL escape
  • Simian immunodeficiency virus
  • Sooty mangabey

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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