Emergence of a subpopulation of lymphocytes bearing theta antigen and complement receptor during tumor growth

R. S. Epstein, Diana M Lopez, G. Ortiz Muniz, M. M. Sigel

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Abstract

Spleens from BALB/c mice transplanted with mammary tumors display a significant increase in the percentage of lymphocytes bearing complement receptors (CRL) while the percentage of cells bearing surface immunoglobulins (SIg) remains unchanged in comparison with that in spleens from normal animals. Upon separation on nylon columns, the increase in CRL in the spleens from tumorbearing mice was limited to the non adherent cell population. Simultaneous marker analysis disclosed that these CRL lacked detectable SIg. Indirect immunofluorescence indicated that these cells possessed theta antigen. Absence of SIg and the presence of theta antigen coupled with the restricted occurrence of these cells in the nylon non adherent population which responded to PHA and Con A but not to LPS indicate that these cells may constitute a subset of T cells. The paucity of this subpopulation of spleen lymphocytes in normal spleen suggests that their emergence is related to tumor growth.

Original languageEnglish
Pages (from-to)458-461
Number of pages4
JournalInternational Journal of Cancer
Volume18
Issue number4
StatePublished - Dec 1 1976

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ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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