Embryoscopic demonstration of hemorrhagic lesions on the human embryo after placental trauma

R. A. Quintero, R. Romero, M. J. Mahoney, A. Abuhamad, M. Vecchio, J. Holden, J. C. Hobbins

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Objective: The purpose of this study was to evaluate embryoscopically the effect of placental trauma on the human embryo. Study design: Patients undergoing elective first-trimester termination of pregnancy underwent transcervical embryoscopy both before and after chorionic villus sampling. If hemorrhagic lesions were not observed on the fetus after chorionic villus sampling, partial placental detachment was performed with a blunt instrument, and the fetus was again observed. Results: Hemorrhagic lesions were observed in 20 of 43 fetuses. In 13 of them, the lesions occurred after placental trauma with the chorionic villus sampling catheter alone (30%), whereas lesions were observed in the remaining seven patients after additional blunt placental disruption. The lesions were located most frequently on the cephalic region, and they grew in size during the observation period. Gestational age or amount of chorionic villus sampling tissue was not different between fetuses with or without lesions. Conclusion: Placental trauma results in embryoscopically demonstrable hemorrhagic lesions on the human embryo. Whereas some of these lesions may be of no consequence, others may lead to permanent changes. If similar lesions occur in deeper tissues, they could cause disruptions in development and conceivably could be related to anomalies reported in infants born to women who have had chorionic villus sampling procedures. Embryoscopy affords the opportunity to study possible mechanisms involved in the occurrence of anomalies.

Original languageEnglish
Pages (from-to)756-759
Number of pages4
JournalAmerican Journal of Obstetrics and Gynecology
Volume168
Issue number3 I
StatePublished - Jan 1 1993

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Chorionic Villi Sampling
Embryonic Structures
Fetus
Fetoscopy
Wounds and Injuries
First Pregnancy Trimester
Gestational Age
Catheters
Head
Observation

Keywords

  • chorionic villus sampling
  • congenital anomalies
  • embryoscopy

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Quintero, R. A., Romero, R., Mahoney, M. J., Abuhamad, A., Vecchio, M., Holden, J., & Hobbins, J. C. (1993). Embryoscopic demonstration of hemorrhagic lesions on the human embryo after placental trauma. American Journal of Obstetrics and Gynecology, 168(3 I), 756-759.

Embryoscopic demonstration of hemorrhagic lesions on the human embryo after placental trauma. / Quintero, R. A.; Romero, R.; Mahoney, M. J.; Abuhamad, A.; Vecchio, M.; Holden, J.; Hobbins, J. C.

In: American Journal of Obstetrics and Gynecology, Vol. 168, No. 3 I, 01.01.1993, p. 756-759.

Research output: Contribution to journalArticle

Quintero, RA, Romero, R, Mahoney, MJ, Abuhamad, A, Vecchio, M, Holden, J & Hobbins, JC 1993, 'Embryoscopic demonstration of hemorrhagic lesions on the human embryo after placental trauma', American Journal of Obstetrics and Gynecology, vol. 168, no. 3 I, pp. 756-759.
Quintero RA, Romero R, Mahoney MJ, Abuhamad A, Vecchio M, Holden J et al. Embryoscopic demonstration of hemorrhagic lesions on the human embryo after placental trauma. American Journal of Obstetrics and Gynecology. 1993 Jan 1;168(3 I):756-759.
Quintero, R. A. ; Romero, R. ; Mahoney, M. J. ; Abuhamad, A. ; Vecchio, M. ; Holden, J. ; Hobbins, J. C. / Embryoscopic demonstration of hemorrhagic lesions on the human embryo after placental trauma. In: American Journal of Obstetrics and Gynecology. 1993 ; Vol. 168, No. 3 I. pp. 756-759.
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