Embryonic transcription factors in human breast cancer

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Growing evidence suggests that breast cancer cells often reactivate latent developmental programs in order to efficiently execute the multi-step process of tumorigenesis. This review focuses on key transcriptional regulators of embryonic development that are deregulated in breast cancer and discusses the molecular mechanisms by which these proteins control carcinogenesis. Reminiscent of their function during development, embryonic transcription factors regulate changes in gene expression that promote tumor cell growth, cell survival and motility, as well as a morphogenetic process called epithelial-mesenchymal transition (EMT), which is implicated in both breast metastasis and tumor recurrence. Because of their pivotal roles in breast tumor progression, these factors represent valuable new biomarkers for breast cancer detection as well as promising new targets for anti-invasive drugs.

Original languageEnglish
Pages (from-to)123-132
Number of pages10
JournalIUBMB Life
Volume58
Issue number3
DOIs
StatePublished - Mar 1 2006

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Tumors
Transcription Factors
Breast Neoplasms
Cells
Cell growth
Embryonic Development
Biomarkers
Carcinogenesis
Gene expression
Epithelial-Mesenchymal Transition
Cell Movement
Cell Survival
Pharmaceutical Preparations
Neoplasm Metastasis
Proteins
Gene Expression
Recurrence
Growth
Neoplasms

Keywords

  • Carcinogenesis
  • Cell cycle
  • Embryogenesis
  • Epithelial-mesenchymal transition
  • Mammary
  • Stem cells
  • Transcription factors

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Embryonic transcription factors in human breast cancer. / Briegel, Karoline.

In: IUBMB Life, Vol. 58, No. 3, 01.03.2006, p. 123-132.

Research output: Contribution to journalArticle

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