Elevation of Serum CEA in Patients with Squamous Cell Carcinoma of the Anus

Gabriel T. Raab, Daniel S. O’Neil, Ravi P. Kiran, Daniel L. Feingold, Steven A. Lee-Kong, David P. Horowitz, Alfred I. Neugut

Research output: Contribution to journalArticlepeer-review


The proportion of anal cancer cases that produce elevated carcinoembryonic antigen (CEA) levels is not well described in the medical literature. In this study, we used electronic health record data from a single urban cancer center to identify patients from 2004–2018 with anal cancer who have also had a pre-initial treatment CEA measurement. We identified 40 patients who met our eligibility criteria. Of those, 11 (27.5%) had an elevated pretreatment CEA. Elevated CEA was not associated with any of the clinical or demographic covariates; however, three out of five patients with a recurrence had an elevated CEA.

Original languageEnglish (US)
Pages (from-to)288-292
Number of pages5
JournalCancer Investigation
Issue number7
StatePublished - 2019
Externally publishedYes


  • Cancer biomarkers
  • carcinoembryonic antigen
  • CEA
  • recurrence
  • squamous cell carcinoma of the anus

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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