Elevation of immunoreactive CSF TRH in depressed patients

C. M. Banki, G. Bissette, M. Arato, C. B. Nemeroff

Research output: Contribution to journalArticlepeer-review

97 Scopus citations


The concentration of thyrotropin-releasing hormone (TRH), a tripeptide (pyroglutamylhistidylprolin-amide), in the CSF of drug-free patients with DSM-III major depression, somatization disorder, and peripheral neurological disorders was measured with a sensitive and specific radioimmunoassay. The depressed patients had markedly higher CSF TRH concentrations than the other patient groups, and this finding could not be attributed to any demographic variables. The elevation of TRH in CSF provides further evidence of hypothalamic-pituitary-thyroid dysfunction in depression.

Original languageEnglish (US)
Pages (from-to)1526-1531
Number of pages6
JournalAmerican Journal of Psychiatry
Issue number12
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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