Elevation of immunoreactive CSF TRH in depressed patients

C. M. Banki, G. Bissette, M. Arato, Charles Nemeroff

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

The concentration of thyrotropin-releasing hormone (TRH), a tripeptide (pyroglutamylhistidylprolin-amide), in the CSF of drug-free patients with DSM-III major depression, somatization disorder, and peripheral neurological disorders was measured with a sensitive and specific radioimmunoassay. The depressed patients had markedly higher CSF TRH concentrations than the other patient groups, and this finding could not be attributed to any demographic variables. The elevation of TRH in CSF provides further evidence of hypothalamic-pituitary-thyroid dysfunction in depression.

Original languageEnglish
Pages (from-to)1526-1531
Number of pages6
JournalAmerican Journal of Psychiatry
Volume145
Issue number12
StatePublished - Dec 1 1988
Externally publishedYes

Fingerprint

Thyrotropin-Releasing Hormone
Depression
Somatoform Disorders
Nervous System Diseases
Amides
Diagnostic and Statistical Manual of Mental Disorders
Radioimmunoassay
Thyroid Gland
Demography
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Banki, C. M., Bissette, G., Arato, M., & Nemeroff, C. (1988). Elevation of immunoreactive CSF TRH in depressed patients. American Journal of Psychiatry, 145(12), 1526-1531.

Elevation of immunoreactive CSF TRH in depressed patients. / Banki, C. M.; Bissette, G.; Arato, M.; Nemeroff, Charles.

In: American Journal of Psychiatry, Vol. 145, No. 12, 01.12.1988, p. 1526-1531.

Research output: Contribution to journalArticle

Banki, CM, Bissette, G, Arato, M & Nemeroff, C 1988, 'Elevation of immunoreactive CSF TRH in depressed patients', American Journal of Psychiatry, vol. 145, no. 12, pp. 1526-1531.
Banki, C. M. ; Bissette, G. ; Arato, M. ; Nemeroff, Charles. / Elevation of immunoreactive CSF TRH in depressed patients. In: American Journal of Psychiatry. 1988 ; Vol. 145, No. 12. pp. 1526-1531.
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