Elevation of CSF somatostatin concentrations in mania

Rajiv P. Sharma, Garth Bissette, Philip G. Janicak, John M. Davis, Charles B. Nemeroff

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Objective: The aim of this study was to compare levels of CSF somatostatin (somatotropin release-inhibiting factor) in drug-free patients with different major psychiatric disorders. Method: CSF somatostatin concentrations were measured in 66 drug-free inpatients with Research Diagnostic Criteria diagnoses of schizophrenia, major depressive disorder, manic disorder, or schizoaffective disorder. Results: In comparison with both the patients with schizophrenia and the patients with schizoaffective disorder, the manic patients had markedly elevated CSF somatostatin concentrations. The depressed patients had significantly higher levels than the schizophrenic patients. Conclusions: Mania is associated with relatively higher CSF somatostatin concentrations.

Original languageEnglish (US)
Pages (from-to)1807-1809
Number of pages3
JournalAmerican Journal of Psychiatry
Issue number12
StatePublished - Dec 1995
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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