Abstract
Objective: The aim of this study was to compare levels of CSF somatostatin (somatotropin release-inhibiting factor) in drug-free patients with different major psychiatric disorders. Method: CSF somatostatin concentrations were measured in 66 drug-free inpatients with Research Diagnostic Criteria diagnoses of schizophrenia, major depressive disorder, manic disorder, or schizoaffective disorder. Results: In comparison with both the patients with schizophrenia and the patients with schizoaffective disorder, the manic patients had markedly elevated CSF somatostatin concentrations. The depressed patients had significantly higher levels than the schizophrenic patients. Conclusions: Mania is associated with relatively higher CSF somatostatin concentrations.
| Original language | English |
|---|---|
| Pages (from-to) | 1807-1809 |
| Number of pages | 3 |
| Journal | American Journal of Psychiatry |
| Volume | 152 |
| Issue number | 12 |
| State | Published - Jan 1 1995 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Psychiatry and Mental health
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Elevation of CSF somatostatin concentrations in mania. / Sharma, R. P.; Bissette, G.; Janicak, P. G.; Davis, J. M.; Nemeroff, Charles.
In: American Journal of Psychiatry, Vol. 152, No. 12, 01.01.1995, p. 1807-1809.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Elevation of CSF somatostatin concentrations in mania
AU - Sharma, R. P.
AU - Bissette, G.
AU - Janicak, P. G.
AU - Davis, J. M.
AU - Nemeroff, Charles
PY - 1995/1/1
Y1 - 1995/1/1
N2 - Objective: The aim of this study was to compare levels of CSF somatostatin (somatotropin release-inhibiting factor) in drug-free patients with different major psychiatric disorders. Method: CSF somatostatin concentrations were measured in 66 drug-free inpatients with Research Diagnostic Criteria diagnoses of schizophrenia, major depressive disorder, manic disorder, or schizoaffective disorder. Results: In comparison with both the patients with schizophrenia and the patients with schizoaffective disorder, the manic patients had markedly elevated CSF somatostatin concentrations. The depressed patients had significantly higher levels than the schizophrenic patients. Conclusions: Mania is associated with relatively higher CSF somatostatin concentrations.
AB - Objective: The aim of this study was to compare levels of CSF somatostatin (somatotropin release-inhibiting factor) in drug-free patients with different major psychiatric disorders. Method: CSF somatostatin concentrations were measured in 66 drug-free inpatients with Research Diagnostic Criteria diagnoses of schizophrenia, major depressive disorder, manic disorder, or schizoaffective disorder. Results: In comparison with both the patients with schizophrenia and the patients with schizoaffective disorder, the manic patients had markedly elevated CSF somatostatin concentrations. The depressed patients had significantly higher levels than the schizophrenic patients. Conclusions: Mania is associated with relatively higher CSF somatostatin concentrations.
UR - http://www.scopus.com/inward/record.url?scp=0028805663&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028805663&partnerID=8YFLogxK
M3 - Article
VL - 152
SP - 1807
EP - 1809
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
SN - 0002-953X
IS - 12
ER -