Elevation of CSF somatostatin concentrations in mania

R. P. Sharma, G. Bissette, P. G. Janicak, J. M. Davis, Charles Nemeroff

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective: The aim of this study was to compare levels of CSF somatostatin (somatotropin release-inhibiting factor) in drug-free patients with different major psychiatric disorders. Method: CSF somatostatin concentrations were measured in 66 drug-free inpatients with Research Diagnostic Criteria diagnoses of schizophrenia, major depressive disorder, manic disorder, or schizoaffective disorder. Results: In comparison with both the patients with schizophrenia and the patients with schizoaffective disorder, the manic patients had markedly elevated CSF somatostatin concentrations. The depressed patients had significantly higher levels than the schizophrenic patients. Conclusions: Mania is associated with relatively higher CSF somatostatin concentrations.

Original languageEnglish
Pages (from-to)1807-1809
Number of pages3
JournalAmerican Journal of Psychiatry
Volume152
Issue number12
StatePublished - Jan 1 1995
Externally publishedYes

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Somatostatin
Bipolar Disorder
Psychotic Disorders
Schizophrenia
Major Depressive Disorder
Pharmaceutical Preparations
Psychiatry
Inpatients
Research

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Sharma, R. P., Bissette, G., Janicak, P. G., Davis, J. M., & Nemeroff, C. (1995). Elevation of CSF somatostatin concentrations in mania. American Journal of Psychiatry, 152(12), 1807-1809.

Elevation of CSF somatostatin concentrations in mania. / Sharma, R. P.; Bissette, G.; Janicak, P. G.; Davis, J. M.; Nemeroff, Charles.

In: American Journal of Psychiatry, Vol. 152, No. 12, 01.01.1995, p. 1807-1809.

Research output: Contribution to journalArticle

Sharma, RP, Bissette, G, Janicak, PG, Davis, JM & Nemeroff, C 1995, 'Elevation of CSF somatostatin concentrations in mania', American Journal of Psychiatry, vol. 152, no. 12, pp. 1807-1809.
Sharma RP, Bissette G, Janicak PG, Davis JM, Nemeroff C. Elevation of CSF somatostatin concentrations in mania. American Journal of Psychiatry. 1995 Jan 1;152(12):1807-1809.
Sharma, R. P. ; Bissette, G. ; Janicak, P. G. ; Davis, J. M. ; Nemeroff, Charles. / Elevation of CSF somatostatin concentrations in mania. In: American Journal of Psychiatry. 1995 ; Vol. 152, No. 12. pp. 1807-1809.
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